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10.1002/wnan.1348

http://scihub22266oqcxt.onion/10.1002/wnan.1348
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C4644720!4644720!25981390
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suck abstract from ncbi


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pmid25981390      Wiley+Interdiscip+Rev+Nanomed+Nanobiotechnol 2016 ; 8 (2): 191-207
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  • Shaping the Future of Nanomedicine: Anisotropy in Polymeric Nanoparticle Design #MMPMID25981390
  • Meyer RA; Green JJ
  • Wiley Interdiscip Rev Nanomed Nanobiotechnol 2016[Mar]; 8 (2): 191-207 PMID25981390show ga
  • Nanofabrication and biomedical applications of polymeric nanoparticles have become important areas of research. Biocompatible polymeric nanoparticles have been investigated for their use as delivery vehicles for therapeutic and diagnostic agents. Although polymeric nanoconstructs have traditionally been fabricated as isotropic spheres, anisotropic, non-spherical nanoparticles have gained interest in the biomaterials community due to their unique interactions with biological systems. Polymeric nanoparticles with different forms of anisotropy have been manufactured utilizing a variety of novel methods in recent years. In addition, they have enhanced physical, chemical, and biological properties compared to spherical nanoparticles, including increased targeting avidity and decreased non-specific in vivo clearance. With these desirable properties, anisotropic nanoparticles have been successfully utilized in many biomedical settings and have performed superiorly to analogous spherical nanoparticles. We summarize the current state-of-the-art fabrication methods for anisotropic polymeric nanoparticles including top-down, bottom-up, and microfluidic design approaches. We also summarize the current and potential future applications of these nanoparticles, including drug delivery, biological targeting, immunoengineering, and tissue engineering. Ongoing research into the properties and utility of anisotropic polymeric nanoparticles will prove critical to realizing their potential in nanomedicine.
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