Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.bone.2014.04.031 http://scihub22266oqcxt.onion/10.1016/j.bone.2014.04.031 C4644668!4644668!24798493     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Bone 2014 ; 65 (ä): 49-59 Nephropedia Template TP {{tp|p=24798493|t=2014. Deletion of Core-binding factor ? (Cbf?) in mesenchymal progenitor cells provides new insights into Cbf?/Runxs complex function in cartilage and bone development |pdf=|usr=}}{{24798493}} gab.com Text Deletion of Core-binding factor (Cbf ) in mesenchymal progenitor cells provides new insights into Cbf /Runxs complex function in cartilage and bone development JO: Bone http://www.kidney.de/pget.php?&tw=1&pmid=24798493 #FOAvip Core-binding factor ? (Cbf?) is a subunit of the Cbf family of heterodimeric transcription factors which plays a critical role in skeletal development through its interaction with the Cbf? subunits, also known as Runt-related transcription factors (Runxs). However, the mechanism by which Cbf? regulates cartilage and bone development remains unclear. Existing Cbf?-deficient mouse models cannot specify the role of Cbf? in skeletal cell lineage. Herein, we sought to specifically address the role of Cbf? in cartilage and bone development by using a conditional knockout (CKO) approach. A mesenchymal-specific Cbf? CKO mouse model was generated by using the Dermo1-Cre mouse line to specifically delete Cbf? in mesenchymal stem cells, which give rise to osteoblasts and chondrocytes. Surprisingly, the mutant mice had under-developed larynx and tracheal cartilage causing alveolus defects which led to death shortly after birth from suffocation. Also, the mutant mice exhibited severe skeletal deformities from defective intramembranous and endochondral ossification, owing to delayed chondrocyte maturation and impaired osteoblast differentiation. Almost all bones of the mutant mice, including the calvariae, vertebrae, tibiae, femurs, ribs, limbs and sternums were defective. Importantly, we showed that Cbf? was expressed throughout the skeleton during both embryonic and postnatal development, which explains the multiple-skeletal defects observed in the mutant mice. Consistently, Cbf? deficiency impaired both chondrocyte proliferation and hypertrophy zone hypertrophy during growth-plate development in the long bones of mutant mice. Notably, Cbf?, Runx1 and Runx2 displayed different expression patterns in the growth plates of the wildtype mice indicating that Cbf?/Runx1 complex and Cbf?/Runx2 complex may regulate chondrocyte proliferation and hypertrophy, respectively, in a spatial and temporal manner. Cbf? deletion in the mesenchymal progenitors impacted bone development by dramatically down-regulating Collagen X (Col X) and Osterix (Osx), but had a dispensable effect on osteoclast development. Collectively, the results demonstrate that Cbf? mediates cartilage and bone development by interacting with Runx1 and Runx2 to regulate the expressions of Col X and Osx for chondrocyte and osteoblast development. These findings not only reveal a critical role for Cbf? in cartilage and bone development, but also facilitate the design of novel therapeutic approaches for skeletal diseases. Twit Text FOAVip Deletion of Core-binding factor (Cbf ) in mesenchymal progenitor cells provides new insights into Cbf /Runxs complex function in cartilage and bone development ????Bone http://www.kidney.de/pget.php?&tw=1&pmid=24798493 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24798493 #FOAvip English Wikipedia <ref>{{Cite pmid|24798493}}</ref> Deletion of Core-binding factor ? (Cbf?) in mesenchymal progenitor cells provides new insights into Cbf?/Runxs complex function in cartilage and bone development #MMPMID24798493 Wu M; Li C; Zhu G; Wang Y; Jules J; Lu Y; McConnell M; Wang YJ; Shao JZ; Li YP; Chen W Bone 2014[Aug]; 65 (ä): 49-59 PMID24798493show ga Core-binding factor ? (Cbf?) is a subunit of the Cbf family of heterodimeric transcription factors which plays a critical role in skeletal development through its interaction with the Cbf? subunits, also known as Runt-related transcription factors (Runxs). However, the mechanism by which Cbf? regulates cartilage and bone development remains unclear. Existing Cbf?-deficient mouse models cannot specify the role of Cbf? in skeletal cell lineage. Herein, we sought to specifically address the role of Cbf? in cartilage and bone development by using a conditional knockout (CKO) approach. A mesenchymal-specific Cbf? CKO mouse model was generated by using the Dermo1-Cre mouse line to specifically delete Cbf? in mesenchymal stem cells, which give rise to osteoblasts and chondrocytes. Surprisingly, the mutant mice had under-developed larynx and tracheal cartilage causing alveolus defects which led to death shortly after birth from suffocation. Also, the mutant mice exhibited severe skeletal deformities from defective intramembranous and endochondral ossification, owing to delayed chondrocyte maturation and impaired osteoblast differentiation. Almost all bones of the mutant mice, including the calvariae, vertebrae, tibiae, femurs, ribs, limbs and sternums were defective. Importantly, we showed that Cbf? was expressed throughout the skeleton during both embryonic and postnatal development, which explains the multiple-skeletal defects observed in the mutant mice. Consistently, Cbf? deficiency impaired both chondrocyte proliferation and hypertrophy zone hypertrophy during growth-plate development in the long bones of mutant mice. Notably, Cbf?, Runx1 and Runx2 displayed different expression patterns in the growth plates of the wildtype mice indicating that Cbf?/Runx1 complex and Cbf?/Runx2 complex may regulate chondrocyte proliferation and hypertrophy, respectively, in a spatial and temporal manner. Cbf? deletion in the mesenchymal progenitors impacted bone development by dramatically down-regulating Collagen X (Col X) and Osterix (Osx), but had a dispensable effect on osteoclast development. Collectively, the results demonstrate that Cbf? mediates cartilage and bone development by interacting with Runx1 and Runx2 to regulate the expressions of Col X and Osx for chondrocyte and osteoblast development. These findings not only reveal a critical role for Cbf? in cartilage and bone development, but also facilitate the design of novel therapeutic approaches for skeletal diseases. äDeletion of Core-binding factor ? (Cbf?) in mesenchymal progenitor cel(epmc).pdf DeepDyve Pubget Overpricing