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10.1186/s13075-015-0841-9 http://scihub22266oqcxt.onion/10.1186/s13075-015-0841-9 C4644627!4644627 !26568428     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26568428 &cmd=llinks): Failed to open stream: HTTP request failed! 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Twenty-eight-week results from the REALISTIC phase IIIb randomized trial: efficacy, safety and predictability of response to certolizumab pegol in a diverse rheumatoid arthritis population |pdf=|usr=}}{{26568428 }} gab.com Text Twenty-eight-week results from the REALISTIC phase IIIb randomized trial: efficacy, safety and predictability of response to certolizumab pegol in a diverse rheumatoid arthritis population JO: Arthritis Res Ther http://www.kidney.de/pget.php?&tw=1&pmid=26568428 #FOAvip INTRODUCTION: This 28-week, phase IIIb study assessed safety and maintenance of response to certolizumab pegol (CZP) in a diverse population of rheumatoid arthritis (RA) patients, stratified by prior anti-TNF exposure, concomitant methotrexate (MTX) use and disease duration. The ability to predict achievement of low disease activity (LDA) at week 28 from improvements in Disease Activity Score 28 (DAS28), erythrocyte sedimentation rate (ESR), swollen joint count (SJC) and Clinical Disease Activity Index (CDAI) up to week 12 was assessed. METHODS: The 28-week study population included all patients who completed the double-blind (DB) phase and entered the open-label (OL) phase, receiving 200 mg CZP every 2 weeks (Q2W) ?16 weeks. In the 12-week DB period, patients with active RA and an inadequate response to ?1 disease-modifying antirheumatic drug (DMARD) were randomized 4:1 to CZP (400 mg at weeks 0, 2 and 4 then 200 mg Q2W) or placebo (Q2W), stratified by prior anti-TNF use, concomitant use of MTX and disease duration (<2 years vs. ?2 years). RESULTS: A total of 955 patients entered the OL phase. At week 28, similar clinical improvements were seen in those receiving CZP throughout (CZP???CZP; n?=?771) and those receiving placebo during the DB phase and switching to CZP in the OL phase (placebo???CZP; n?=?184) (ACR20 response rate?=?59.7% vs. 53.3%; ACR50/ACR70 response rates were also similar). Effect of CZP treatment was similar regardless of prior anti-TNF use, disease duration and concomitant DMARDs, based on ACR20 response rates. The percentage of patients achieving DAS28(ESR) LDA at week 28 was calculated for DAS28(ESR), SJC or CDAI responders at earlier time points. Reductions from baseline (?) of DAS28(ESR) <1.2, ?SJC <25% or ?CDAI <10 by week 12 were associated with <9% chance of achieving LDA at week 28 regardless of prior anti-TNF exposure. Adverse event rates were similar for placebo???CZP and CZP???CZP patients, with no new safety signals identified. CONCLUSIONS: A diverse population of RA patients with varying disease duration showed rapid and sustained clinical improvements on CZP treatment, regardless of prior anti-TNF or concomitant DMARD use. Failure to achieve improvements in DAS28(ESR), SJC or CDAI within the first 12 weeks of CZP therapy was associated with a low chance of achieving LDA at week 28. No new safety signals were observed. TRIAL REGISTRATION: ClinicalTrials.gov, NCT00717236 , 15 July 2008. Twit Text FOAVip Twenty-eight-week results from the REALISTIC phase IIIb randomized trial: efficacy, safety and predictability of response to certolizumab pegol in a diverse rheumatoid arthritis population ????Arthritis Res Ther http://www.kidney.de/pget.php?&tw=1&pmid=26568428 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26568428 #FOAvip English Wikipedia <ref>{{Cite pmid|26568428 }}</ref> Twenty-eight-week results from the REALISTIC phase IIIb randomized trial: efficacy, safety and predictability of response to certolizumab pegol in a diverse rheumatoid arthritis population #MMPMID26568428 Weinblatt ME ; Fleischmann R ; van Vollenhoven RF ; Emery P ; Huizinga TW ; Cutolo M ; van der Heijde D ; Duncan B ; Davies O ; Luijtens K ; Dougados M Arthritis Res Ther 2015[Nov]; 17 (ä): 325 PMID26568428 show ga INTRODUCTION: This 28-week, phase IIIb study assessed safety and maintenance of response to certolizumab pegol (CZP) in a diverse population of rheumatoid arthritis (RA) patients, stratified by prior anti-TNF exposure, concomitant methotrexate (MTX) use and disease duration. The ability to predict achievement of low disease activity (LDA) at week 28 from improvements in Disease Activity Score 28 (DAS28), erythrocyte sedimentation rate (ESR), swollen joint count (SJC) and Clinical Disease Activity Index (CDAI) up to week 12 was assessed. METHODS: The 28-week study population included all patients who completed the double-blind (DB) phase and entered the open-label (OL) phase, receiving 200 mg CZP every 2 weeks (Q2W) ?16 weeks. In the 12-week DB period, patients with active RA and an inadequate response to ?1 disease-modifying antirheumatic drug (DMARD) were randomized 4:1 to CZP (400 mg at weeks 0, 2 and 4 then 200 mg Q2W) or placebo (Q2W), stratified by prior anti-TNF use, concomitant use of MTX and disease duration (<2 years vs. ?2 years). RESULTS: A total of 955 patients entered the OL phase. At week 28, similar clinical improvements were seen in those receiving CZP throughout (CZP???CZP; n?=?771) and those receiving placebo during the DB phase and switching to CZP in the OL phase (placebo???CZP; n?=?184) (ACR20 response rate?=?59.7% vs. 53.3%; ACR50/ACR70 response rates were also similar). Effect of CZP treatment was similar regardless of prior anti-TNF use, disease duration and concomitant DMARDs, based on ACR20 response rates. The percentage of patients achieving DAS28(ESR) LDA at week 28 was calculated for DAS28(ESR), SJC or CDAI responders at earlier time points. Reductions from baseline (?) of DAS28(ESR) <1.2, ?SJC <25% or ?CDAI <10 by week 12 were associated with <9% chance of achieving LDA at week 28 regardless of prior anti-TNF exposure. Adverse event rates were similar for placebo???CZP and CZP???CZP patients, with no new safety signals identified. CONCLUSIONS: A diverse population of RA patients with varying disease duration showed rapid and sustained clinical improvements on CZP treatment, regardless of prior anti-TNF or concomitant DMARD use. Failure to achieve improvements in DAS28(ESR), SJC or CDAI within the first 12 weeks of CZP therapy was associated with a low chance of achieving LDA at week 28. No new safety signals were observed. TRIAL REGISTRATION: ClinicalTrials.gov, NCT00717236 , 15 July 2008. |Aged [MESH] |Antirheumatic Agents/adverse effects/*therapeutic use [MESH] |Arthritis, Rheumatoid/blood/*diagnosis/*drug therapy [MESH] |Certolizumab Pegol/adverse effects/*therapeutic use [MESH] |Double-Blind Method [MESH] |Female [MESH] |Follow-Up Studies [MESH] |Humans [MESH] |Inflammation Mediators/antagonists & inhibitors/blood [MESH] |Male [MESH] |Middle Aged [MESH] |Nasopharyngitis/chemically induced [MESH] |Predictive Value of Tests [MESH] |Time Factors [MESH]Twenty-eight-week results from the REALISTIC phase IIIb randomized tri(epmc).pdf DeepDyve Pubget Overpricing