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10.1146/annurev-cellbio-100814-125438 http://scihub22266oqcxt.onion/10.1146/annurev-cellbio-100814-125438 C4644480!4644480!26436706     free     free     free       Annu+Rev+Cell+Dev+Biol 2015 ; 31 (ä): 83-108 Nephropedia Template TP {{tp|p=26436706|t=2015. Mechanism and Regulation of Cytoplasmic Dynein |pdf=|usr=}}{{26436706}} gab.com Text Mechanism and Regulation of Cytoplasmic Dynein JO: Annu Rev Cell Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=26436706 #FOAvip Until recently, dynein was the least understood of the cytoskeletal motors. However, a wealth of new structural, mechanistic, and cell biological data is shedding light on how this complicated minus-end?directed, microtubule-based motor works. Cytoplasmic dynein-1 performs a wide array of functions in most eukaryotes, both in interphase, in which it transports organelles, proteins, mRNAs, and viruses, and in mitosis and meiosis. Mutations in dynein or its regulators are linked to neurodevelopmental and neurodegenerative diseases. Here, we begin by providing a synthesis of recent data to describe the current model of dynein?s mechanochemical cycle. Next, we discuss regulators of dynein, with particular focus on those that directly interact with the motor to modulate its recruitment to microtubules, initiate cargo transport, or activate minus-end?directed motility. Twit Text FOAVip Mechanism and Regulation of Cytoplasmic Dynein ????Annu Rev Cell Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=26436706 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26436706 #FOAvip English Wikipedia <ref>{{Cite pmid|26436706}}</ref> Mechanism and Regulation of Cytoplasmic Dynein #MMPMID26436706 Cianfrocco MA; DeSantis ME; Leschziner AE; Reck-Peterson SL Annu Rev Cell Dev Biol 2015[Nov]; 31 (ä): 83-108 PMID26436706show ga Until recently, dynein was the least understood of the cytoskeletal motors. However, a wealth of new structural, mechanistic, and cell biological data is shedding light on how this complicated minus-end?directed, microtubule-based motor works. Cytoplasmic dynein-1 performs a wide array of functions in most eukaryotes, both in interphase, in which it transports organelles, proteins, mRNAs, and viruses, and in mitosis and meiosis. Mutations in dynein or its regulators are linked to neurodevelopmental and neurodegenerative diseases. Here, we begin by providing a synthesis of recent data to describe the current model of dynein?s mechanochemical cycle. Next, we discuss regulators of dynein, with particular focus on those that directly interact with the motor to modulate its recruitment to microtubules, initiate cargo transport, or activate minus-end?directed motility. äMechanism and Regulation of Cytoplasmic Dynein (epmc).pdf DeepDyve Pubget Overpricing