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10.1016/j.cell.2015.10.017 http://scihub22266oqcxt.onion/10.1016/j.cell.2015.10.017 C4644223!4644223!26522593     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2015 ; 163 (4): 866-79 Nephropedia Template TP {{tp|p=26522593|t=2015. Relaxation of Loaded ESCRT-III Spiral Springs Drives Membrane Deformation |pdf=|usr=}}{{26522593}} gab.com Text Relaxation of Loaded ESCRT-III Spiral Springs Drives Membrane Deformation JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=26522593 #FOAvip ESCRT-III is required for lipid membrane remodeling in many cellular processes, from abscission to viral budding and multi-vesicular body biogenesis. However, how ESCRT-III polymerization generates membrane curvature remains debated. Here, we show that Snf7, the main component of ESCRT-III, polymerizes into spirals at the surface of lipid bilayers. When covering the entire membrane surface, these spirals stopped growing when densely packed: they had a polygonal shape, suggesting that lateral compression could deform them. We reasoned that Snf7 spirals could function as spiral springs. By measuring the polymerization energy and the rigidity of Snf7 filaments, we showed that they were deformed while growing in a confined area. Furthermore, we observed that the elastic expansion of compressed Snf7 spirals generated an area difference between the two sides of the membrane and thus curvature. This spring-like activity underlies the driving force by which ESCRT-III could mediate membrane deformation and fission. Twit Text FOAVip Relaxation of Loaded ESCRT-III Spiral Springs Drives Membrane Deformation ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=26522593 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26522593 #FOAvip English Wikipedia <ref>{{Cite pmid|26522593}}</ref> Relaxation of Loaded ESCRT-III Spiral Springs Drives Membrane Deformation #MMPMID26522593 Chiaruttini N; Redondo-Morata L; Colom A; Humbert F; Lenz M; Scheuring S; Roux A Cell 2015[Nov]; 163 (4): 866-79 PMID26522593show ga ESCRT-III is required for lipid membrane remodeling in many cellular processes, from abscission to viral budding and multi-vesicular body biogenesis. However, how ESCRT-III polymerization generates membrane curvature remains debated. Here, we show that Snf7, the main component of ESCRT-III, polymerizes into spirals at the surface of lipid bilayers. When covering the entire membrane surface, these spirals stopped growing when densely packed: they had a polygonal shape, suggesting that lateral compression could deform them. We reasoned that Snf7 spirals could function as spiral springs. By measuring the polymerization energy and the rigidity of Snf7 filaments, we showed that they were deformed while growing in a confined area. Furthermore, we observed that the elastic expansion of compressed Snf7 spirals generated an area difference between the two sides of the membrane and thus curvature. This spring-like activity underlies the driving force by which ESCRT-III could mediate membrane deformation and fission. äRelaxation of Loaded ESCRT-III Spiral Springs Drives Membrane Deformat(epmc).pdf DeepDyve Pubget Overpricing