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10.1016/j.bmcl.2015.04.019 http://scihub22266oqcxt.onion/10.1016/j.bmcl.2015.04.019 C4643947!4643947!25937010     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Bioorg+Med+Chem+Lett 2015 ; 25 (11): 2261-8 Nephropedia Template TP {{tp|p=25937010|t=2015. Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway |pdf=|usr=}}{{25937010}} gab.com Text Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway JO: Bioorg Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=25937010 #FOAvip Nrf2 is the major transcription factor that regulates many of the cytoprotective enzymes involved in the adaptive stress response. Modulation of Nrf2 could be therapeutically useful in a number of disease states. Activation can occur through either an electrophilic or non-electrophilic mechanism. To date, most of the research has focused on electrophilic Nrf2 activators, but there is increasing interest in non-electrophilic modulators of Nrf2. This Digest examines the current selection of small molecules that modulate Nrf2 through non-electrophilic mechanisms, and it highlights new opportunities for this important therapeutic target. Twit Text FOAVip Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway ????Bioorg Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=25937010 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25937010 #FOAvip English Wikipedia <ref>{{Cite pmid|25937010}}</ref> Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway #MMPMID25937010 Richardson BG; Jain AD; Speltz TE; Moore TW Bioorg Med Chem Lett 2015[Jun]; 25 (11): 2261-8 PMID25937010show ga Nrf2 is the major transcription factor that regulates many of the cytoprotective enzymes involved in the adaptive stress response. Modulation of Nrf2 could be therapeutically useful in a number of disease states. Activation can occur through either an electrophilic or non-electrophilic mechanism. To date, most of the research has focused on electrophilic Nrf2 activators, but there is increasing interest in non-electrophilic modulators of Nrf2. This Digest examines the current selection of small molecules that modulate Nrf2 through non-electrophilic mechanisms, and it highlights new opportunities for this important therapeutic target. äNon-electrophilic modulators of the canonical Keap1/Nrf2 pathway (epmc).pdf DeepDyve Pubget Overpricing