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2015 ; 19
(ä): 400
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Does inferior vena cava respiratory variability predict fluid responsiveness in
spontaneously breathing patients?
#MMPMID26563768
Airapetian N
; Maizel J
; Alyamani O
; Mahjoub Y
; Lorne E
; Levrard M
; Ammenouche N
; Seydi A
; Tinturier F
; Lobjoie E
; Dupont H
; Slama M
Crit Care
2015[Nov]; 19
(ä): 400
PMID26563768
show ga
INTRODUCTION: We have almost no information concerning the value of inferior vena
cava (IVC) respiratory variations in spontaneously breathing ICU patients (SBP)
to predict fluid responsiveness. METHODS: SBP with clinical fluid need were
included prospectively in the study. Echocardiography and Doppler ultrasound were
used to record the aortic velocity-time integral (VTI), stroke volume (SV),
cardiac output (CO) and IVC collapsibility index (cIVC) ((maximum diameter
(IVCmax)- minimum diameter (IVCmin))/ IVCmax) at baseline, after a passive
leg-raising maneuver (PLR) and after 500 ml of saline infusion. RESULTS:
Fifty-nine patients (30 males and 29 females; 57?±?18 years-old) were included in
the study. Of these, 29 (49 %) were considered to be responders (?10 % increase
in CO after fluid infusion). There were no significant differences between
responders and nonresponders at baseline, except for a higher aortic VTI in
nonresponders (16 cm vs. 19 cm, p?=?0.03). Responders had a lower baseline IVCmin
than nonresponders (11?±?5 mm vs. 14?±?5 mm, p?=?0.04) and more marked IVC
variations (cIVC: 35?±?16 vs. 27?±?10 %, p?=?0.04). Prediction of
fluid-responsiveness using cIVC and IVCmax was low (area under the curve for cIVC
at baseline 0.62?±?0.07; 95 %, CI 0.49-0.74 and for IVCmax at baseline
0.62?±?0.07; 95 % CI 0.49-0.75). In contrast, IVC respiratory variations >42 % in
SBP demonstrated a high specificity (97 %) and a positive predictive value (90 %)
to predict an increase in CO after fluid infusion. CONCLUSIONS: In SBP with
suspected hypovolemia, vena cava size and respiratory variability do not predict
fluid responsiveness. In contrast, a cIVC >42 % may predict an increase in CO
after fluid infusion.