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10.3109/10428194.2015.1030638 http://scihub22266oqcxt.onion/10.3109/10428194.2015.1030638 C4643417!4643417 !25797560     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25797560 &cmd=llinks): Failed to open stream: HTTP request failed! 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A phase 2 study of the BH3 mimetic BCL2 inhibitor navitoclax (ABT-263) with or without rituximab, in previously untreated B-cell chronic lymphocytic leukemia |pdf=|usr=}}{{25797560 }} gab.com Text A phase 2 study of the BH3 mimetic BCL2 inhibitor navitoclax (ABT-263) with or without rituximab, in previously untreated B-cell chronic lymphocytic leukemia JO: Leuk Lymphoma http://www.kidney.de/pget.php?&tw=1&pmid=25797560 #FOAvip We evaluated the safety and biologic activity of the BH3 mimetic protein, navitoclax, combined with rituximab, in comparison to rituximab alone. One hundred and eighteen patients with chronic lymphocytic leukemia (CLL) were randomized to receive eight weekly doses of rituximab (arm A), eight weekly doses of rituximab plus daily navitoclax for 12 weeks (arm B) or eight weekly doses of rituximab plus daily navitoclax until disease progression or unacceptable toxicity (arm C). Investigator-assessed overall response rates (complete [CR] and partial [PR]) were 35% (arm A), 55% (arm B, p = 0.19 vs. A) and 70% (arm C, p = 0.0034 vs. A). Patients with del(17p) or high levels of BCL2 had significantly better clinical responses when treated with navitoclax. Navitoclax in combination with rituximab was well tolerated as initial therapy for patients with CLL, yielded higher response rates than rituximab alone and resulted in prolonged progression-free survival with treatment beyond 12 weeks. Twit Text FOAVip A phase 2 study of the BH3 mimetic BCL2 inhibitor navitoclax (ABT-263) with or without rituximab, in previously untreated B-cell chronic lymphocytic leukemia ????Leuk Lymphoma http://www.kidney.de/pget.php?&tw=1&pmid=25797560 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25797560 #FOAvip English Wikipedia <ref>{{Cite pmid|25797560 }}</ref> A phase 2 study of the BH3 mimetic BCL2 inhibitor navitoclax (ABT-263) with or without rituximab, in previously untreated B-cell chronic lymphocytic leukemia #MMPMID25797560 Kipps TJ ; Eradat H ; Grosicki S ; Catalano J ; Cosolo W ; Dyagil IS ; Yalamanchili S ; Chai A ; Sahasranaman S ; Punnoose E ; Hurst D ; Pylypenko H Leuk Lymphoma 2015[]; 56 (10 ): 2826-33 PMID25797560 show ga We evaluated the safety and biologic activity of the BH3 mimetic protein, navitoclax, combined with rituximab, in comparison to rituximab alone. One hundred and eighteen patients with chronic lymphocytic leukemia (CLL) were randomized to receive eight weekly doses of rituximab (arm A), eight weekly doses of rituximab plus daily navitoclax for 12 weeks (arm B) or eight weekly doses of rituximab plus daily navitoclax until disease progression or unacceptable toxicity (arm C). Investigator-assessed overall response rates (complete [CR] and partial [PR]) were 35% (arm A), 55% (arm B, p = 0.19 vs. A) and 70% (arm C, p = 0.0034 vs. A). Patients with del(17p) or high levels of BCL2 had significantly better clinical responses when treated with navitoclax. Navitoclax in combination with rituximab was well tolerated as initial therapy for patients with CLL, yielded higher response rates than rituximab alone and resulted in prolonged progression-free survival with treatment beyond 12 weeks. |Adult [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Aniline Compounds/administration & dosage/*therapeutic use [MESH] |Antineoplastic Combined Chemotherapy Protocols/adverse effects/*therapeutic use [MESH] |Biomarkers [MESH] |Female [MESH] |Humans [MESH] |Kaplan-Meier Estimate [MESH] |Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis/*drug therapy/mortality [MESH] |Male [MESH] |Middle Aged [MESH] |Proto-Oncogene Proteins c-bcl-2/*antagonists & inhibitors/metabolism [MESH] |Rituximab/administration & dosage [MESH] |Sulfonamides/administration & dosage/*therapeutic use [MESH]A phase 2 study of the BH3 mimetic BCL2 inhibitor navitoclax (ABT-263)(epmc).pdf DeepDyve Pubget Overpricing