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10.1016/j.neuron.2015.09.025 http://scihub22266oqcxt.onion/10.1016/j.neuron.2015.09.025 C4643308!4643308 !26481037     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26481037 &cmd=llinks): Failed to open stream: HTTP request failed! 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Hebbian and Homeostatic Plasticity Mechanisms in Regular Spiking and Intrinsic Bursting Cells of Cortical Layer 5 |pdf=|usr=}}{{26481037 }} gab.com Text Hebbian and Homeostatic Plasticity Mechanisms in Regular Spiking and Intrinsic Bursting Cells of Cortical Layer 5 JO: Neuron http://www.kidney.de/pget.php?&tw=1&pmid=26481037 #FOAvip Layer 5 contains the major projection neurons of the neocortex and is composed of two major cell types: regular spiking (RS) cells, which have cortico-cortical projections, and intrinsic bursting cells (IB), which have subcortical projections. Little is known about the plasticity processes and specifically the molecular mechanisms by which these two cell classes develop and maintain their unique integrative properties. In this study, we find that RS and IB cells show fundementally different experience-dependent plasticity processes and integrate Hebbian and homeostatic components of plasticity differently. Both RS and IB cells showed TNF?-dependent homeostatic plasticity in response to sensory deprivation, but IB cells were capable of a much faster synaptic depression and homeostatic rebound than RS cells. Only IB cells showed input-specific potentiation that depended on CaMKII autophosphorylation. Our findings demonstrate that plasticity mechanisms are not uniform within the neocortex, even within a cortical layer, but are specialized within subcircuits. Twit Text FOAVip Hebbian and Homeostatic Plasticity Mechanisms in Regular Spiking and Intrinsic Bursting Cells of Cortical Layer 5 ????Neuron http://www.kidney.de/pget.php?&tw=1&pmid=26481037 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26481037 #FOAvip English Wikipedia <ref>{{Cite pmid|26481037 }}</ref> Hebbian and Homeostatic Plasticity Mechanisms in Regular Spiking and Intrinsic Bursting Cells of Cortical Layer 5 #MMPMID26481037 Greenhill SD ; Ranson A ; Fox K Neuron 2015[Nov]; 88 (3 ): 539-52 PMID26481037 show ga Layer 5 contains the major projection neurons of the neocortex and is composed of two major cell types: regular spiking (RS) cells, which have cortico-cortical projections, and intrinsic bursting cells (IB), which have subcortical projections. Little is known about the plasticity processes and specifically the molecular mechanisms by which these two cell classes develop and maintain their unique integrative properties. In this study, we find that RS and IB cells show fundementally different experience-dependent plasticity processes and integrate Hebbian and homeostatic components of plasticity differently. Both RS and IB cells showed TNF?-dependent homeostatic plasticity in response to sensory deprivation, but IB cells were capable of a much faster synaptic depression and homeostatic rebound than RS cells. Only IB cells showed input-specific potentiation that depended on CaMKII autophosphorylation. Our findings demonstrate that plasticity mechanisms are not uniform within the neocortex, even within a cortical layer, but are specialized within subcircuits. |Action Potentials/*physiology [MESH] |Animals [MESH] |Homeostasis/*physiology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Mice, Transgenic [MESH] |Neocortex/*physiology [MESH] |Neuronal Plasticity/*physiology [MESH] |Neurons/*physiology [MESH] |Somatosensory Cortex/physiology [MESH] |Synapses/physiology [MESH]Hebbian and Homeostatic Plasticity Mechanisms in Regular Spiking and I(epmc).pdf DeepDyve Pubget Overpricing