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10.1038/srep16449 http://scihub22266oqcxt.onion/10.1038/srep16449 C4643246!4643246 !26563570     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26563570 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2015 ; 5 (ä): 16449 Nephropedia Template TP {{tp|p=26563570 |t=2015. Combined deficiency of Notch1 and Notch3 causes pericyte dysfunction, models CADASIL, and results in arteriovenous malformations |pdf=|usr=}}{{26563570 }} gab.com Text Combined deficiency of Notch1 and Notch3 causes pericyte dysfunction, models CADASIL, and results in arteriovenous malformations JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26563570 #FOAvip Pericytes regulate vessel stability and pericyte dysfunction contributes to retinopathies, stroke, and cancer. Here we define Notch as a key regulator of pericyte function during angiogenesis. In Notch1(+/-); Notch3(-/-) mice, combined deficiency of Notch1 and Notch3 altered pericyte interaction with the endothelium and reduced pericyte coverage of the retinal vasculature. Notch1 and Notch3 were shown to cooperate to promote proper vascular basement membrane formation and contribute to endothelial cell quiescence. Accordingly, loss of pericyte function due to Notch deficiency exacerbates endothelial cell activation caused by Notch1 haploinsufficiency. Mice mutant for Notch1 and Notch3 develop arteriovenous malformations and display hallmarks of the ischemic stroke disease CADASIL. Thus, Notch deficiency compromises pericyte function and contributes to vascular pathologies. Twit Text FOAVip Combined deficiency of Notch1 and Notch3 causes pericyte dysfunction, models CADASIL, and results in arteriovenous malformations ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26563570 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26563570 #FOAvip English Wikipedia <ref>{{Cite pmid|26563570 }}</ref> Combined deficiency of Notch1 and Notch3 causes pericyte dysfunction, models CADASIL, and results in arteriovenous malformations #MMPMID26563570 Kofler NM ; Cuervo H ; Uh MK ; Murtomäki A ; Kitajewski J Sci Rep 2015[Nov]; 5 (ä): 16449 PMID26563570 show ga Pericytes regulate vessel stability and pericyte dysfunction contributes to retinopathies, stroke, and cancer. Here we define Notch as a key regulator of pericyte function during angiogenesis. In Notch1(+/-); Notch3(-/-) mice, combined deficiency of Notch1 and Notch3 altered pericyte interaction with the endothelium and reduced pericyte coverage of the retinal vasculature. Notch1 and Notch3 were shown to cooperate to promote proper vascular basement membrane formation and contribute to endothelial cell quiescence. Accordingly, loss of pericyte function due to Notch deficiency exacerbates endothelial cell activation caused by Notch1 haploinsufficiency. Mice mutant for Notch1 and Notch3 develop arteriovenous malformations and display hallmarks of the ischemic stroke disease CADASIL. Thus, Notch deficiency compromises pericyte function and contributes to vascular pathologies. |Animals [MESH] |Arteriovenous Malformations/*genetics/metabolism [MESH] |Blotting, Western [MESH] |CADASIL/*genetics/metabolism [MESH] |Cell Differentiation/genetics [MESH] |Cells, Cultured [MESH] |Disease Models, Animal [MESH] |Endothelial Cells/metabolism/pathology/ultrastructure [MESH] |Gene Expression [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Matrix Metalloproteinase 2/genetics/metabolism [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Microscopy, Confocal [MESH] |Microscopy, Electron, Transmission [MESH] |Muscle, Smooth, Vascular/metabolism/pathology [MESH] |Pericytes/*metabolism/pathology/ultrastructure [MESH] |Receptor, Notch1/deficiency/*genetics [MESH] |Receptor, Notch3 [MESH] |Receptor, Platelet-Derived Growth Factor beta/genetics/metabolism [MESH] |Receptors, Notch/deficiency/*genetics [MESH] |Retinal Vessels/metabolism/pathology/physiopathology [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH]Combined deficiency of Notch1 and Notch3 causes pericyte dysfunction, (epmc).pdf DeepDyve Pubget Overpricing