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10.1016/j.chom.2015.05.011 http://scihub22266oqcxt.onion/10.1016/j.chom.2015.05.011 C4642999!4642999 !26067604     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26067604 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26067604 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Host+Microbe 2015 ; 17 (6 ): 775-87 Nephropedia Template TP {{tp|p=26067604 |t=2015. Synergistic Action of Staphylococcus aureus ?-Toxin on Platelets and Myeloid Lineage Cells Contributes to Lethal Sepsis |pdf=|usr=}}{{26067604 }} gab.com Text Synergistic Action of Staphylococcus aureus -Toxin on Platelets and Myeloid Lineage Cells Contributes to Lethal Sepsis JO: Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=26067604 #FOAvip Multi-organ failure contributes to mortality in bacterial sepsis. Platelet and immune cell activation contribute to organ injury during sepsis, but the mechanisms by which bacterial virulence factors initiate these responses remain poorly defined. We demonstrate that during lethal sepsis, Staphylococcus aureus ?-toxin simultaneously alters platelet activation and promotes neutrophil inflammatory signaling through interactions with its cellular receptor ADAM10. Platelet intoxication prevents endothelial barrier repair and facilitates formation of injurious platelet-neutrophil aggregates, contributing to lung and liver injury that is mitigated by ADAM10 deletion on platelets and myeloid lineage cells. While platelet- or myeloid-specific ADAM10 knockout does not alter sepsis mortality, double-knockout animals are highly protected. These results define a pathway by which a single bacterial toxin utilizes a widely expressed receptor to coordinate progressive, multi-organ disease in lethal sepsis. As an expression-enhancing ADAM10 polymorphism confers susceptibility to severe human sepsis, these studies highlight the importance of understanding molecular host-microbe interactions. Twit Text FOAVip Synergistic Action of Staphylococcus aureus -Toxin on Platelets and Myeloid Lineage Cells Contributes to Lethal Sepsis ????Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=26067604 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26067604 #FOAvip English Wikipedia <ref>{{Cite pmid|26067604 }}</ref> Synergistic Action of Staphylococcus aureus ?-Toxin on Platelets and Myeloid Lineage Cells Contributes to Lethal Sepsis #MMPMID26067604 Powers ME ; Becker RE ; Sailer A ; Turner JR ; Bubeck Wardenburg J Cell Host Microbe 2015[Jun]; 17 (6 ): 775-87 PMID26067604 show ga Multi-organ failure contributes to mortality in bacterial sepsis. Platelet and immune cell activation contribute to organ injury during sepsis, but the mechanisms by which bacterial virulence factors initiate these responses remain poorly defined. We demonstrate that during lethal sepsis, Staphylococcus aureus ?-toxin simultaneously alters platelet activation and promotes neutrophil inflammatory signaling through interactions with its cellular receptor ADAM10. Platelet intoxication prevents endothelial barrier repair and facilitates formation of injurious platelet-neutrophil aggregates, contributing to lung and liver injury that is mitigated by ADAM10 deletion on platelets and myeloid lineage cells. While platelet- or myeloid-specific ADAM10 knockout does not alter sepsis mortality, double-knockout animals are highly protected. These results define a pathway by which a single bacterial toxin utilizes a widely expressed receptor to coordinate progressive, multi-organ disease in lethal sepsis. As an expression-enhancing ADAM10 polymorphism confers susceptibility to severe human sepsis, these studies highlight the importance of understanding molecular host-microbe interactions. |*Host-Pathogen Interactions [MESH] |ADAM Proteins/genetics/*metabolism [MESH] |ADAM10 Protein [MESH] |Acute Lung Injury/physiopathology [MESH] |Amyloid Precursor Protein Secretases/genetics/*metabolism [MESH] |Animals [MESH] |Bacteremia/*microbiology/mortality/physiopathology [MESH] |Bacterial Toxins/metabolism/*toxicity [MESH] |Blood Platelets/*drug effects/pathology [MESH] |Cell Lineage/drug effects [MESH] |Hemolysin Proteins/metabolism/*toxicity [MESH] |Humans [MESH] |Interleukin-1beta/metabolism [MESH] |Liver/metabolism/pathology [MESH] |Membrane Proteins/genetics/*metabolism [MESH] |Mice, Knockout [MESH] |Mice, Transgenic [MESH] |Neutrophils/pathology [MESH]Synergistic Action of Staphylococcus aureus ?-Toxin on Platelets and M(epmc).pdf DeepDyve Pubget Overpricing