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10.2147/BTT.S54179 http://scihub22266oqcxt.onion/10.2147/BTT.S54179 C4642804!4642804 !26604681     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26604681 &cmd=llinks): Failed to open stream: HTTP request failed! 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Advanced basal cell carcinoma, the hedgehog pathway, and treatment options - role of smoothened inhibitors |pdf=|usr=}}{{26604681 }} gab.com Text Advanced basal cell carcinoma, the hedgehog pathway, and treatment options - role of smoothened inhibitors JO: Biologics http://www.kidney.de/pget.php?&tw=1&pmid=26604681 #FOAvip Cutaneous basal cell carcinoma (BCC) is the most common human cancer and its incidence is rising worldwide. Ultraviolet radiation exposure, including tanning bed use, as well as host factors play a role in its development. The majority of cases are treated and cured with local therapies including surgery. Yet, the health care costs of diagnosis and treatment of BCCs in the US is substantial. In the United States, the cost of nonmelanoma skin cancer care in the Medicare population is estimated to be US$426 million per year. While rare, locally advanced BCCs that can no longer be controlled with surgery and/or radiation, and metastatic BCCs do occur and can be associated with significant morbidity and mortality. Vismodegib (GDC-0449), a smoothened inhibitor targeted at the hedgehog pathway, is the first US Food and Drug Association (FDA)-approved agent in the treatment of locally advanced, unresectable, and metastatic BCCs. This class of agents appears to be changing the survival rates in advanced BCC patients, but appropriate patient selection and monitoring are important. Multidisciplinary assessments are essential for the optimal care and management of these patients. For some patients with locally advanced BCC, treatment with a hedgehog inhibitor may eliminate the need for an excessively disfiguring or morbid surgery. Twit Text FOAVip Advanced basal cell carcinoma, the hedgehog pathway, and treatment options - role of smoothened inhibitors ????Biologics http://www.kidney.de/pget.php?&tw=1&pmid=26604681 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26604681 #FOAvip English Wikipedia <ref>{{Cite pmid|26604681 }}</ref> Advanced basal cell carcinoma, the hedgehog pathway, and treatment options - role of smoothened inhibitors #MMPMID26604681 Fecher LA ; Sharfman WH Biologics 2015[]; 9 (ä): 129-40 PMID26604681 show ga Cutaneous basal cell carcinoma (BCC) is the most common human cancer and its incidence is rising worldwide. Ultraviolet radiation exposure, including tanning bed use, as well as host factors play a role in its development. The majority of cases are treated and cured with local therapies including surgery. Yet, the health care costs of diagnosis and treatment of BCCs in the US is substantial. In the United States, the cost of nonmelanoma skin cancer care in the Medicare population is estimated to be US$426 million per year. While rare, locally advanced BCCs that can no longer be controlled with surgery and/or radiation, and metastatic BCCs do occur and can be associated with significant morbidity and mortality. Vismodegib (GDC-0449), a smoothened inhibitor targeted at the hedgehog pathway, is the first US Food and Drug Association (FDA)-approved agent in the treatment of locally advanced, unresectable, and metastatic BCCs. This class of agents appears to be changing the survival rates in advanced BCC patients, but appropriate patient selection and monitoring are important. Multidisciplinary assessments are essential for the optimal care and management of these patients. For some patients with locally advanced BCC, treatment with a hedgehog inhibitor may eliminate the need for an excessively disfiguring or morbid surgery. äAdvanced basal cell carcinoma, the hedgehog pathway, and treatment opt(epmc).pdf DeepDyve Pubget Overpricing