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Association between dental amalgam fillings and Alzheimer s disease: a
population-based cross-sectional study in Taiwan
#MMPMID26560125
Sun YH
; Nfor ON
; Huang JY
; Liaw YP
Alzheimers Res Ther
2015[Nov]; 7
(1
): 65
PMID26560125
show ga
INTRODUCTION: The potential effects of amalgam fillings on the development of
Alzheimer's disease (AD) are not well understood. The aim of the study was to
evaluate the association between dental amalgam fillings and Alzheimer's disease
in Taiwanese population aged 65 and older. METHODS: Data were retrieved from the
Longitudinal Health Insurance Database (LHID 2005 and 2010). The study enrolled
1,943,702 beneficiaries from the LHID database. After excluding death cases and
individuals aged 65 and under, 207,587 enrollees were finally involved in the
study. Dental amalgam fillings are coded as 89001C, 89002C, 89003C, 89101C,
89102C, or 89103C in the national health insurance research database (NHIRD).
Alzheimer's disease was diagnosed using the International Classification of
Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes 331.0. RESULTS:
Individuals exposed to amalgam fillings had higher risk of Alzheimer's disease
(odds ratio, OR?=?1.105, 95 % confidence interval, CI?=?1.025-1.190) than their
non-exposed counterparts. Further analysis showed that the odds ratio of
Ahlzheimer's disease was 1.07 (95 % CI?=?0.962-1.196) in men and 1.132 (95 %
CI?=?1.022-1.254) in women. CONCLUSIONS: Women who were exposed to amalgam
fillings were 1.132 times more likely to have Alzheimer's disease than were their
non-exposed counterparts.
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