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10.1038/srep16437 http://scihub22266oqcxt.onion/10.1038/srep16437 C4642332!4642332 !26561336     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26561336 &cmd=llinks): Failed to open stream: HTTP request failed! 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Inhibition of A20 expression in tumor microenvironment exerts anti-tumor effect through inducing myeloid-derived suppressor cells apoptosis |pdf=|usr=}}{{26561336 }} gab.com Text Inhibition of A20 expression in tumor microenvironment exerts anti-tumor effect through inducing myeloid-derived suppressor cells apoptosis JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26561336 #FOAvip Myeloid-derived suppressor cells (MDSCs) are known to play important roles in the development of immunosuppressive tumor microenvironment. A20 is a zinc-finger protein which could negatively regulate apoptosis in several cell types. However, the role of A20 in tumor microenvironment remains largely unknown. In this study, we found that A20 was over-expressed in MDSCs. The treatment of tumor-bearing mice with small interfering RNA targeting A20 (si-A20) inhibited the growth of tumors. The infiltration of MDSCs was dramatically reduced after si-A20 treatment, as compared to control groups, whereas the numbers of dendritic cells and macrophages were not affected. Also, injection of si-A20 improved T cell mediated tumor-specific immune response. Depletion of MDSCs with anti-Gr1 antibody showed similar antitumor effect and improved T cell response. TNF-? was highly expressed after si-A20 injection. Furthermore, si-A20 induced apoptosis of MDSCs in the presence of TNF-? both in vivo and in vitro. Cleaved Caspase-3 and Caspase-8 were elevated with the activation of JNK pathway after the induction of MDSC apoptosis by si-A20. Thus, our findings suggested that knockdown of A20 in tumor site inhibited tumor growth at least through inducing the apoptosis of MDSCs. A20 might be a potential target in anticancer therapy. Twit Text FOAVip Inhibition of A20 expression in tumor microenvironment exerts anti-tumor effect through inducing myeloid-derived suppressor cells apoptosis ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26561336 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26561336 #FOAvip English Wikipedia <ref>{{Cite pmid|26561336 }}</ref> Inhibition of A20 expression in tumor microenvironment exerts anti-tumor effect through inducing myeloid-derived suppressor cells apoptosis #MMPMID26561336 Shao B ; Wei X ; Luo M ; Yu J ; Tong A ; Ma X ; Ye T ; Deng H ; Sang Y ; Liang X ; Ma Y ; Wu Q ; Du W ; Du J ; Gao X ; Wen Y ; Fu P ; Shi H ; Luo S ; Wei Y Sci Rep 2015[Nov]; 5 (ä): 16437 PMID26561336 show ga Myeloid-derived suppressor cells (MDSCs) are known to play important roles in the development of immunosuppressive tumor microenvironment. A20 is a zinc-finger protein which could negatively regulate apoptosis in several cell types. However, the role of A20 in tumor microenvironment remains largely unknown. In this study, we found that A20 was over-expressed in MDSCs. The treatment of tumor-bearing mice with small interfering RNA targeting A20 (si-A20) inhibited the growth of tumors. The infiltration of MDSCs was dramatically reduced after si-A20 treatment, as compared to control groups, whereas the numbers of dendritic cells and macrophages were not affected. Also, injection of si-A20 improved T cell mediated tumor-specific immune response. Depletion of MDSCs with anti-Gr1 antibody showed similar antitumor effect and improved T cell response. TNF-? was highly expressed after si-A20 injection. Furthermore, si-A20 induced apoptosis of MDSCs in the presence of TNF-? both in vivo and in vitro. Cleaved Caspase-3 and Caspase-8 were elevated with the activation of JNK pathway after the induction of MDSC apoptosis by si-A20. Thus, our findings suggested that knockdown of A20 in tumor site inhibited tumor growth at least through inducing the apoptosis of MDSCs. A20 might be a potential target in anticancer therapy. |*Gene Expression [MESH] |Animals [MESH] |Apoptosis/*genetics/*immunology [MESH] |Cell Line, Tumor [MESH] |Cysteine Endopeptidases/*genetics [MESH] |Disease Models, Animal [MESH] |Gene Knockdown Techniques [MESH] |Humans [MESH] |Immune Tolerance [MESH] |Intracellular Signaling Peptides and Proteins/*genetics [MESH] |Lymphocyte Activation/genetics/immunology [MESH] |MAP Kinase Signaling System [MESH] |Melanoma, Experimental [MESH] |Mice [MESH] |Myeloid Cells/*immunology/*metabolism [MESH] |Neoplasms/genetics/immunology/metabolism/pathology [MESH] |RNA, Small Interfering/genetics [MESH] |T-Lymphocytes/immunology/metabolism [MESH] |Tumor Microenvironment/*genetics/*immunology [MESH]Inhibition of A20 expression in tumor microenvironment exerts anti-tum(epmc).pdf DeepDyve Pubget Overpricing