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10.1212/WNL.0000000000001940 http://scihub22266oqcxt.onion/10.1212/WNL.0000000000001940 C4642147!4642147!26296517     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neurology 2015 ; 85 (18): 1604-13 Nephropedia Template TP {{tp|p=26296517|t=2015. New-onset refractory status epilepticus: Etiology, clinical features, and outcome |pdf=|usr=}}{{26296517}} gab.com Text New-onset refractory status epilepticus: Etiology, clinical features, and outcome JO: Neurology http://www.kidney.de/pget.php?&tw=1&pmid=26296517 #FOAvip Objectives:: The aims of this study were to determine the etiology, clinical features, and predictors of outcome of new-onset refractory status epilepticus. Methods:: Retrospective review of patients with refractory status epilepticus without etiology identified within 48 hours of admission between January 1, 2008, and December 31, 2013, in 13 academic medical centers. The primary outcome measure was poor functional outcome at discharge (defined as a score >3 on the modified Rankin Scale). Results:: Of 130 cases, 67 (52%) remained cryptogenic. The most common identified etiologies were autoimmune (19%) and paraneoplastic (18%) encephalitis. Full data were available in 125 cases (62 cryptogenic). Poor outcome occurred in 77 of 125 cases (62%), and 28 (22%) died. Predictors of poor outcome included duration of status epilepticus, use of anesthetics, and medical complications. Among the 63 patients with available follow-up data (median 9 months), functional status improved in 36 (57%); 79% had good or fair outcome at last follow-up, but epilepsy developed in 37% with most survivors (92%) remaining on antiseizure medications. Immune therapies were used less frequently in cryptogenic cases, despite a comparable prevalence of inflammatory CSF changes. Conclusions:: Autoimmune encephalitis is the most commonly identified cause of new-onset refractory status epilepticus, but half remain cryptogenic. Outcome at discharge is poor but improves during follow-up. Epilepsy develops in most cases. The role of anesthetics and immune therapies warrants further investigation. Twit Text FOAVip New-onset refractory status epilepticus: Etiology, clinical features, and outcome ????Neurology http://www.kidney.de/pget.php?&tw=1&pmid=26296517 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26296517 #FOAvip English Wikipedia <ref>{{Cite pmid|26296517}}</ref> New-onset refractory status epilepticus: Etiology, clinical features, and outcome #MMPMID26296517 Gaspard N; Foreman BP; Alvarez V; Cabrera Kang C; Probasco JC; Jongeling AC; Meyers E; Espinera A; Haas KF; Schmitt SE; Gerard EE; Gofton T; Kaplan PW; Lee JW; Legros B; Szaflarski JP; Westover BM; LaRoche SM; Hirsch LJ; Fertig E; Herman ST; Huh L; Lee JW; Loddenkemper T; Chapman K; Abend NS; Carpenter J; Hantus S; Claassen J; Husain AM; Gaspard N; LaRoche SM; Ritzl EK; Gofton T; Wusthoff C; Goldstein J; Westover BM; Hocker S; Halford J; Jones J; Gerard EE; Schmitt SE; Williams K; Hahn CD; Szaflarski JP; Kramer A; Rudzinski L; Hopp J; Mani R; Kalamangalam GP; Gupta P; Quigg MS; Haas KF; Ostendorf A; Zutshi D; Hirsch LJ Neurology 2015[Nov]; 85 (18): 1604-13 PMID26296517show ga Objectives:: The aims of this study were to determine the etiology, clinical features, and predictors of outcome of new-onset refractory status epilepticus. Methods:: Retrospective review of patients with refractory status epilepticus without etiology identified within 48 hours of admission between January 1, 2008, and December 31, 2013, in 13 academic medical centers. The primary outcome measure was poor functional outcome at discharge (defined as a score >3 on the modified Rankin Scale). Results:: Of 130 cases, 67 (52%) remained cryptogenic. The most common identified etiologies were autoimmune (19%) and paraneoplastic (18%) encephalitis. Full data were available in 125 cases (62 cryptogenic). Poor outcome occurred in 77 of 125 cases (62%), and 28 (22%) died. Predictors of poor outcome included duration of status epilepticus, use of anesthetics, and medical complications. Among the 63 patients with available follow-up data (median 9 months), functional status improved in 36 (57%); 79% had good or fair outcome at last follow-up, but epilepsy developed in 37% with most survivors (92%) remaining on antiseizure medications. Immune therapies were used less frequently in cryptogenic cases, despite a comparable prevalence of inflammatory CSF changes. Conclusions:: Autoimmune encephalitis is the most commonly identified cause of new-onset refractory status epilepticus, but half remain cryptogenic. Outcome at discharge is poor but improves during follow-up. Epilepsy develops in most cases. The role of anesthetics and immune therapies warrants further investigation. äNew-onset refractory status epilepticus: Etiology, clinical features, (epmc).pdf DeepDyve Pubget Overpricing