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10.1155/2015/817604

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suck abstract from ncbi


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pmid26605346
      J+Immunol+Res 2015 ; 2015 (ä): 817604
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  • The Novel Functions of the PLC/PKC/PKD Signaling Axis in G Protein-Coupled Receptor-Mediated Chemotaxis of Neutrophils #MMPMID26605346
  • Xu X ; Jin T
  • J Immunol Res 2015[]; 2015 (ä): 817604 PMID26605346 show ga
  • Chemotaxis, a directional cell migration guided by extracellular chemoattractant gradients, plays an essential role in the recruitment of neutrophils to sites of inflammation. Chemotaxis is mediated by the G protein-coupled receptor (GPCR) signaling pathway. Extracellular stimuli trigger activation of the PLC/PKC/PKD signaling axis, which controls several signaling pathways. Here, we concentrate on the novel functions of PLC/PKC/PKD signaling in GPCR-mediated chemotaxis of neutrophils.
  • |*Chemotaxis/immunology [MESH]
  • |*Signal Transduction [MESH]
  • |Animals [MESH]
  • |Humans [MESH]
  • |Isoenzymes [MESH]
  • |Neutrophils/*immunology/*metabolism [MESH]
  • |Protein Kinase C/*metabolism [MESH]
  • |Receptors, G-Protein-Coupled/*metabolism [MESH]


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