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10.3389/fphys.2015.00327 http://scihub22266oqcxt.onion/10.3389/fphys.2015.00327 C4641914!4641914!26617530     free     free     free       Front+Physiol 2015 ; 6 (ä): ä Nephropedia Template TP {{tp|p=26617530|t=2015. The Role of Krüppel-like Factor 4 in Renal Fibrosis |pdf=|usr=}}{{26617530}} gab.com Text The Role of Krüppel-like Factor 4 in Renal Fibrosis JO: Front Physiol http://www.kidney.de/pget.php?&tw=1&pmid=26617530 #FOAvip Chronic kidney disease (CKD) caused by renal fibrosis is an important public health concern. It is therefore necessary to understand the molecular pathogenesis of renal fibrosis in order to develop novel therapeutic strategies. KLF4 is the most extensively studied factor among the various members of the Krüppel-like factor (KLF) family of zinc finger-containing transcription factors. Many studies have demonstrated that KLF4 inhibits the activation of myofibroblasts and exerts an inhibitory effect on fibrosis. However, other studies have indicated that KLF4 may promote renal fibrosis. These controversial results suggest that KLF4 may be crucially involved in the development of renal fibrosis, although the underlying mechanism(s) remain unclear. Here, we summarize the recent progress made in understanding the role of KLF4 in renal fibrosis. Together, these findings suggest that KLF4 may participate in the development of renal fibrosis, but that its inhibition of fibrosis is greater than its promotion of the condition, which suggests that KLF4 may serve as a novel therapeutic target for renal fibrosis. Twit Text FOAVip The Role of Krüppel-like Factor 4 in Renal Fibrosis ????Front Physiol http://www.kidney.de/pget.php?&tw=1&pmid=26617530 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26617530 #FOAvip English Wikipedia <ref>{{Cite pmid|26617530}}</ref> The Role of Krüppel-like Factor 4 in Renal Fibrosis #MMPMID26617530 Ke B; Zhang A; Wu X; Fang X Front Physiol 2015[]; 6 (ä): ä PMID26617530show ga Chronic kidney disease (CKD) caused by renal fibrosis is an important public health concern. It is therefore necessary to understand the molecular pathogenesis of renal fibrosis in order to develop novel therapeutic strategies. KLF4 is the most extensively studied factor among the various members of the Krüppel-like factor (KLF) family of zinc finger-containing transcription factors. Many studies have demonstrated that KLF4 inhibits the activation of myofibroblasts and exerts an inhibitory effect on fibrosis. However, other studies have indicated that KLF4 may promote renal fibrosis. These controversial results suggest that KLF4 may be crucially involved in the development of renal fibrosis, although the underlying mechanism(s) remain unclear. Here, we summarize the recent progress made in understanding the role of KLF4 in renal fibrosis. Together, these findings suggest that KLF4 may participate in the development of renal fibrosis, but that its inhibition of fibrosis is greater than its promotion of the condition, which suggests that KLF4 may serve as a novel therapeutic target for renal fibrosis. äThe Role of Krüppel-like Factor 4 in Renal Fibrosis (epmc).pdf DeepDyve Pubget Overpricing