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10.15252/embj.201591803 http://scihub22266oqcxt.onion/10.15252/embj.201591803 C4641532!4641532 !26346275     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26346275 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       EMBO+J 2015 ; 34 (21 ): 2671-85 Nephropedia Template TP {{tp|p=26346275 |t=2015. Suppression of miR-199a maturation by HuR is crucial for hypoxia-induced glycolytic switch in hepatocellular carcinoma |pdf=|usr=}}{{26346275 }} gab.com Text Suppression of miR-199a maturation by HuR is crucial for hypoxia-induced glycolytic switch in hepatocellular carcinoma JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=26346275 #FOAvip Glucose metabolic reprogramming is a hallmark of cancer. Cancer cells rapidly adjust their energy source from oxidative phosphorylation to glycolytic metabolism in order to efficiently proliferate in a hypoxic environment, but the mechanism underlying this switch is still incompletely understood. Here, we report that hypoxia potently induces the RNA-binding protein HuR to specifically bind primary miR-199a transcript to block miR-199a maturation in hepatocellular carcinoma (HCC) cells. We demonstrate that this hypoxia-suppressed miR-199a plays a decisive role in limiting glycolysis in HCC cells by targeting hexokinase-2 (Hk2) and pyruvate kinase-M2 (Pkm2). Furthermore, systemically delivered cholesterol-modified agomiR-199a inhibits [(18)F]-fluorodeoxyglucose uptake and attenuates tumor growth in HCC tumor-bearing mice. These data reveal a novel mechanism of reprogramming of cancer energy metabolism in which HuR suppresses miR-199a maturation to link hypoxia to the Warburg effect and suggest a promising therapeutic strategy that targets miR-199a to interrupt cancerous aerobic glycolysis. Twit Text FOAVip Suppression of miR-199a maturation by HuR is crucial for hypoxia-induced glycolytic switch in hepatocellular carcinoma ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=26346275 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26346275 #FOAvip English Wikipedia <ref>{{Cite pmid|26346275 }}</ref> Suppression of miR-199a maturation by HuR is crucial for hypoxia-induced glycolytic switch in hepatocellular carcinoma #MMPMID26346275 Zhang LF ; Lou JT ; Lu MH ; Gao C ; Zhao S ; Li B ; Liang S ; Li Y ; Li D ; Liu MF EMBO J 2015[Nov]; 34 (21 ): 2671-85 PMID26346275 show ga Glucose metabolic reprogramming is a hallmark of cancer. Cancer cells rapidly adjust their energy source from oxidative phosphorylation to glycolytic metabolism in order to efficiently proliferate in a hypoxic environment, but the mechanism underlying this switch is still incompletely understood. Here, we report that hypoxia potently induces the RNA-binding protein HuR to specifically bind primary miR-199a transcript to block miR-199a maturation in hepatocellular carcinoma (HCC) cells. We demonstrate that this hypoxia-suppressed miR-199a plays a decisive role in limiting glycolysis in HCC cells by targeting hexokinase-2 (Hk2) and pyruvate kinase-M2 (Pkm2). Furthermore, systemically delivered cholesterol-modified agomiR-199a inhibits [(18)F]-fluorodeoxyglucose uptake and attenuates tumor growth in HCC tumor-bearing mice. These data reveal a novel mechanism of reprogramming of cancer energy metabolism in which HuR suppresses miR-199a maturation to link hypoxia to the Warburg effect and suggest a promising therapeutic strategy that targets miR-199a to interrupt cancerous aerobic glycolysis. |*Gene Expression Regulation, Neoplastic [MESH] |Animals [MESH] |Base Sequence [MESH] |Carcinoma, Hepatocellular/*genetics/metabolism [MESH] |Carrier Proteins/genetics/metabolism [MESH] |Cell Hypoxia [MESH] |Cell Line, Tumor [MESH] |ELAV-Like Protein 1/*physiology [MESH] |Glycolysis [MESH] |Hexokinase/genetics/metabolism [MESH] |Humans [MESH] |Liver Neoplasms/*genetics/metabolism [MESH] |Male [MESH] |Membrane Proteins/genetics/metabolism [MESH] |Mice, Inbred BALB C [MESH] |Mice, Nude [MESH] |MicroRNAs/*genetics/metabolism [MESH] |Neoplasm Transplantation [MESH] |Protein Binding [MESH] |Thyroid Hormone-Binding Proteins [MESH]Suppression of miR-199a maturation by HuR is crucial for hypoxia-induc(epmc).pdf DeepDyve Pubget Overpricing