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10.1038/jid.2015.242 http://scihub22266oqcxt.onion/10.1038/jid.2015.242 C4641324!4641324!26121213     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Invest+Dermatol 2015 ; 135 (11): 2753-63 Nephropedia Template TP {{tp|p=26121213|t=2015. The Androgen Receptor Antagonizes Wnt/?-Catenin Signaling in Epidermal Stem Cells |pdf=|usr=}}{{26121213}} gab.com Text The Androgen Receptor Antagonizes Wnt/ -Catenin Signaling in Epidermal Stem Cells JO: J Invest Dermatol http://www.kidney.de/pget.php?&tw=1&pmid=26121213 #FOAvip Activation of Wnt/?-catenin signaling in adult mouse epidermis leads to expansion of the stem cell compartment and redirects keratinocytes in the interfollicular epidermis and sebaceous glands (SGs) to differentiate along the hair follicle (HF) lineages. Here we demonstrate that during epidermal development and homeostasis there is reciprocal activation of the androgen receptor (AR) and ?-catenin in cells of the HF bulb. AR activation reduced ?-catenin-dependent transcription, blocked ?-catenin-induced induction of HF growth, and prevented ?-catenin-mediated conversion of SGs into HFs. Conversely, AR inhibition enhanced the effects of ?-catenin activation, promoting HF proliferation and differentiation, culminating in the formation of benign HF tumors and a complete loss of SG identity. We conclude that AR signaling has a key role in epidermal stem cell fate selection by modulating responses to ?-catenin in adult mouse skin. Twit Text FOAVip The Androgen Receptor Antagonizes Wnt/ -Catenin Signaling in Epidermal Stem Cells ????J Invest Dermatol http://www.kidney.de/pget.php?&tw=1&pmid=26121213 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26121213 #FOAvip English Wikipedia <ref>{{Cite pmid|26121213}}</ref> The Androgen Receptor Antagonizes Wnt/?-Catenin Signaling in Epidermal Stem Cells #MMPMID26121213 Kretzschmar K; Cottle DL; Schweiger PJ; Watt FM J Invest Dermatol 2015[Nov]; 135 (11): 2753-63 PMID26121213show ga Activation of Wnt/?-catenin signaling in adult mouse epidermis leads to expansion of the stem cell compartment and redirects keratinocytes in the interfollicular epidermis and sebaceous glands (SGs) to differentiate along the hair follicle (HF) lineages. Here we demonstrate that during epidermal development and homeostasis there is reciprocal activation of the androgen receptor (AR) and ?-catenin in cells of the HF bulb. AR activation reduced ?-catenin-dependent transcription, blocked ?-catenin-induced induction of HF growth, and prevented ?-catenin-mediated conversion of SGs into HFs. Conversely, AR inhibition enhanced the effects of ?-catenin activation, promoting HF proliferation and differentiation, culminating in the formation of benign HF tumors and a complete loss of SG identity. We conclude that AR signaling has a key role in epidermal stem cell fate selection by modulating responses to ?-catenin in adult mouse skin. äThe Androgen Receptor Antagonizes Wnt/?-Catenin Signaling in Epidermal(epmc).pdf DeepDyve Pubget Overpricing