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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Pak+J+Med+Sci
2015 ; 31
(5
): 1182-7
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Pattern of MRI brain in neuro-psychiatric SLE Effect of anti-phospholipid
antibodies: A study at a tertiary care teaching hospital
#MMPMID26649010
Parvez K
; Al-Arfaj AR
; Hamdani MA
; Naseeb F
; Daif A
; Hussain S
Pak J Med Sci
2015[Sep]; 31
(5
): 1182-7
PMID26649010
show ga
OBJECTIVE: To compare the neuro-radiologic findings in Systemic lupus
erythematosus (SLE) patients with and without antiphospholipid antibodies (aPL)
in different neuro-psychiatric manifestations. METHODS: This cross-sectional
comparative study was carried out at King Khalid University Hospital, a tertiary
care teaching hospital, Riyadh, Saudi Arabia from June 2012 to January 2015.
Ninety seven SLE patients with neuro-psychiatric manifestations were included in
the study and divided into two groups. Group I (50 patients) SLE with aPL and
group II (47 patients) SLE without aPL. We compared Demographic features,
clinical manifestations and magnetic resonance imaging (MRI) brain findings.
RESULTS: Demographic and clinical characteristics of two groups were similar. In
Group-I, anticardiolipin antibodies (aCL) were most common (86%). In patients
with headache, most of the patients in Group-I had white matter hyperintensities
(WMHIs) (50% vs 27%) while most of the patients in Group-II had normal MRI brain
(38% vs 73%). Similarly WMHIs were found more in Group-I patients with seizures
(60% vs 21%), while ischemia/infarction, atrophy and normal MRI were found in
Group-II. MRI brain in patients with neurological deficit and psychiatric
disorder were not much different in both the groups. CONCLUSION: We found no
statistically significant differences in frequencies of MRI brain abnormalities
in SLE patients with and without aPL antibodies. Each of the three aPL may have a
variable effect on the brain.
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