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10.5483/bmbrep.2015.48.9.140 http://scihub22266oqcxt.onion/10.5483/bmbrep.2015.48.9.140 C4641237!4641237 !26246285     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26246285 &cmd=llinks): Failed to open stream: HTTP request failed! 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Wnt5a attenuates the pathogenic effects of the Wnt/?-catenin pathway in human retinal pigment epithelial cells via down-regulating ?-catenin and Snail |pdf=|usr=}}{{26246285 }} gab.com Text Wnt5a attenuates the pathogenic effects of the Wnt/ -catenin pathway in human retinal pigment epithelial cells via down-regulating -catenin and Snail JO: BMB Rep http://www.kidney.de/pget.php?&tw=1&pmid=26246285 #FOAvip Activation of the Wnt/?-catenin pathway plays a pathogenic role in age-related macular degeneration (AMD) and is thus a potential target for the development of therapeutics for this disease. Here, we demonstrated that Wnt5a antagonized ?-catenin response transcription (CRT) induced with Wnt3a by promoting ?-catenin phosphorylation at Ser33/Ser37/Thr41 and its subsequent degradation in human retinal pigment epithelial (RPE) cells. Wnt5a decreased the levels of vascular endothelial growth factor (VEGF), tumor necrosis factor-? (TNF-?), and nuclear factor-?B (NF-?B), which was up-regulated by Wnt3a. Furthermore, Wnt5a increased E-cadherin expression and decreased cell migration by down-regulating Snail expression, thereby abrogating the Wnt3a-induced epithelial-mesenchymal transition (EMT) in human RPE cells. Our findings suggest that Wnt5a suppresses the pathogenic effects of canonical Wnt signaling in human RPE cells by promoting ?-catenin phosphorylation and degradation. Therefore, Wnt5a has significant therapeutic potential for the treatment of AMD. Twit Text FOAVip Wnt5a attenuates the pathogenic effects of the Wnt/ -catenin pathway in human retinal pigment epithelial cells via down-regulating -catenin and Snail ????BMB Rep http://www.kidney.de/pget.php?&tw=1&pmid=26246285 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26246285 #FOAvip English Wikipedia <ref>{{Cite pmid|26246285 }}</ref> Wnt5a attenuates the pathogenic effects of the Wnt/?-catenin pathway in human retinal pigment epithelial cells via down-regulating ?-catenin and Snail #MMPMID26246285 Kim JH ; Park S ; Chung H ; Oh S BMB Rep 2015[Sep]; 48 (9 ): 525-30 PMID26246285 show ga Activation of the Wnt/?-catenin pathway plays a pathogenic role in age-related macular degeneration (AMD) and is thus a potential target for the development of therapeutics for this disease. Here, we demonstrated that Wnt5a antagonized ?-catenin response transcription (CRT) induced with Wnt3a by promoting ?-catenin phosphorylation at Ser33/Ser37/Thr41 and its subsequent degradation in human retinal pigment epithelial (RPE) cells. Wnt5a decreased the levels of vascular endothelial growth factor (VEGF), tumor necrosis factor-? (TNF-?), and nuclear factor-?B (NF-?B), which was up-regulated by Wnt3a. Furthermore, Wnt5a increased E-cadherin expression and decreased cell migration by down-regulating Snail expression, thereby abrogating the Wnt3a-induced epithelial-mesenchymal transition (EMT) in human RPE cells. Our findings suggest that Wnt5a suppresses the pathogenic effects of canonical Wnt signaling in human RPE cells by promoting ?-catenin phosphorylation and degradation. Therefore, Wnt5a has significant therapeutic potential for the treatment of AMD. |Angiogenesis Inducing Agents/pharmacology [MESH] |Cells, Cultured [MESH] |Down-Regulation [MESH] |Epithelial-Mesenchymal Transition/drug effects [MESH] |Humans [MESH] |Macular Degeneration/drug therapy [MESH] |NF-kappa B/metabolism [MESH] |Phosphorylation [MESH] |Proto-Oncogene Proteins/*pharmacology [MESH] |Retinal Pigment Epithelium/cytology/*drug effects/metabolism [MESH] |Snail Family Transcription Factors [MESH] |Transcription Factors/metabolism [MESH] |Tumor Necrosis Factor-alpha/metabolism [MESH] |Vascular Endothelial Growth Factor A/metabolism [MESH] |Wnt Proteins/*pharmacology [MESH] |Wnt Signaling Pathway/*drug effects [MESH] |Wnt-5a Protein [MESH]Wnt5a attenuates the pathogenic effects of the Wnt/?-catenin pathway i(epmc).pdf DeepDyve Pubget Overpricing