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10.1155/2015/406269 http://scihub22266oqcxt.onion/10.1155/2015/406269 C4641198!4641198!26604925     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Endocrinol 2015 ; 2015 (ä): ä Nephropedia Template TP {{tp|p=26604925|t=2015. Association between Serum Soluble Klotho Levels and Mortality in Chronic Hemodialysis Patients |pdf=|usr=}}{{26604925}} gab.com Text Association between Serum Soluble Klotho Levels and Mortality in Chronic Hemodialysis Patients JO: Int J Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=26604925 #FOAvip Klotho is a single-pass transmembrane protein predominantly expressed in the kidney. The extracellular domain of Klotho is subject to ectodomain shedding and is released into the circulation as a soluble form. Soluble Klotho is also generated from alternative splicing of the Klotho gene. In mice, defects in Klotho expression lead to complex phenotypes resembling those observed in dialysis patients. However, the relationship between the level of serum soluble Klotho and overall survival in hemodialysis patients, who exhibit a state of Klotho deficiency, remains to be delineated. Here we prospectively followed a cohort of 63 patients with a mean duration of chronic hemodialysis of 6.7 ± 5.4 years for a median of 65 months. Serum soluble Klotho was detectable in all patients (median 371?pg/mL, interquartile range 309?449). Patients with serum soluble Klotho levels below the lower quartile (<309?pg/mL) had significantly higher cardiovascular and all-cause mortality rates. Furthermore, the higher all-cause mortality persisted even after adjustment for confounders (hazard ratio 4.14, confidence interval 1.29?13.48). We conclude that there may be a threshold for the serum soluble Klotho level associated with a higher risk of mortality. Twit Text FOAVip Association between Serum Soluble Klotho Levels and Mortality in Chronic Hemodialysis Patients ????Int J Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=26604925 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26604925 #FOAvip English Wikipedia <ref>{{Cite pmid|26604925}}</ref> Association between Serum Soluble Klotho Levels and Mortality in Chronic Hemodialysis Patients #MMPMID26604925 Otani-Takei N; Masuda T; Akimoto T; Honma S; Watanabe Y; Shiizaki K; Miki T; Kusano E; Asano Y; Kuro-o M; Nagata D Int J Endocrinol 2015[]; 2015 (ä): ä PMID26604925show ga Klotho is a single-pass transmembrane protein predominantly expressed in the kidney. The extracellular domain of Klotho is subject to ectodomain shedding and is released into the circulation as a soluble form. Soluble Klotho is also generated from alternative splicing of the Klotho gene. In mice, defects in Klotho expression lead to complex phenotypes resembling those observed in dialysis patients. However, the relationship between the level of serum soluble Klotho and overall survival in hemodialysis patients, who exhibit a state of Klotho deficiency, remains to be delineated. Here we prospectively followed a cohort of 63 patients with a mean duration of chronic hemodialysis of 6.7 ± 5.4 years for a median of 65 months. Serum soluble Klotho was detectable in all patients (median 371?pg/mL, interquartile range 309?449). Patients with serum soluble Klotho levels below the lower quartile (<309?pg/mL) had significantly higher cardiovascular and all-cause mortality rates. Furthermore, the higher all-cause mortality persisted even after adjustment for confounders (hazard ratio 4.14, confidence interval 1.29?13.48). We conclude that there may be a threshold for the serum soluble Klotho level associated with a higher risk of mortality. äAssociation between Serum Soluble Klotho Levels and Mortality in Chron(epmc).pdf DeepDyve Pubget Overpricing