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10.1016/j.jaci.2015.03.049

http://scihub22266oqcxt.onion/10.1016/j.jaci.2015.03.049
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C4641025!4641025!26078103
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suck abstract from ncbi


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pmid26078103      J+Allergy+Clin+Immunol 2015 ; 136 (5): 1150-62
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  • Insights into Primary Immune Deficiency from quantitative microscopy analysis #MMPMID26078103
  • Mace EM; Orange JS
  • J Allergy Clin Immunol 2015[Nov]; 136 (5): 1150-62 PMID26078103show ga
  • Recent advances in genomics based technology have resulted in an increase in our understanding of the molecular basis of many primary immune deficiencies. Along with this increased knowledge comes an increased responsibility to understand the underlying mechanism of disease, and thus increasingly sophisticated technologies are being used to investigate the cell biology of human immune deficiencies. One such technology, which has, itself, undergone a recent explosion in innovation, is that of high-resolution microscopy and image analysis. These advances complement innovative studies that have previously shed light on critical cell biological processes that are perturbed by single gene mutations in primary immune deficiency. Here, we highlight advances made specifically in the following cell biological processes: 1) cytoskeletal-related processes; 2) cell signaling; 3) intercellular trafficking; and 4) cellular host defense.
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