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10.1016/j.tips.2015.07.004 http://scihub22266oqcxt.onion/10.1016/j.tips.2015.07.004 C4641009!4641009!26434644     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Trends+Pharmacol+Sci 2015 ; 36 (11): 782-97 Nephropedia Template TP {{tp|p=26434644|t=2015. Pharmacological modulation of the N-end rule pathway and its therapeutic implications |pdf=|usr=}}{{26434644}} gab.com Text Pharmacological modulation of the N-end rule pathway and its therapeutic implications JO: Trends Pharmacol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26434644 #FOAvip The N-end rule pathway is a proteolytic system in which single N-terminal amino acids of short-lived substrates determine their metabolic half-lives. Substrates of this pathway have been implicated in the pathogenesis of many diseases, including malignancies, neurodegeneration, and cardiovascular disorders. This review provides a comprehensive overview of current knowledge about the mechanism and functions of the N-end rule pathway. Pharmacological strategies for the modulation of target substrate degradation are also reviewed, with emphasis on their in vivo implications. Given the rapid advances in structural and biochemical understanding of the recognition components (N-recognins) of the N-end rule pathway, small-molecule inhibitors and activating ligands of N-recognins emerge as therapeutic agents with novel mechanisms of action. Twit Text FOAVip Pharmacological modulation of the N-end rule pathway and its therapeutic implications ????Trends Pharmacol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26434644 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26434644 #FOAvip English Wikipedia <ref>{{Cite pmid|26434644}}</ref> Pharmacological modulation of the N-end rule pathway and its therapeutic implications #MMPMID26434644 Lee JH; Jiang Y; Kwon YT; Lee MJ Trends Pharmacol Sci 2015[Nov]; 36 (11): 782-97 PMID26434644show ga The N-end rule pathway is a proteolytic system in which single N-terminal amino acids of short-lived substrates determine their metabolic half-lives. Substrates of this pathway have been implicated in the pathogenesis of many diseases, including malignancies, neurodegeneration, and cardiovascular disorders. This review provides a comprehensive overview of current knowledge about the mechanism and functions of the N-end rule pathway. Pharmacological strategies for the modulation of target substrate degradation are also reviewed, with emphasis on their in vivo implications. Given the rapid advances in structural and biochemical understanding of the recognition components (N-recognins) of the N-end rule pathway, small-molecule inhibitors and activating ligands of N-recognins emerge as therapeutic agents with novel mechanisms of action. äPharmacological modulation of the N-end rule pathway and its therapeut(epmc).pdf DeepDyve Pubget Overpricing