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10.1016/j.it.2015.09.004 http://scihub22266oqcxt.onion/10.1016/j.it.2015.09.004 C4640954!4640954!26474675     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Trends+Immunol 2015 ; 36 (11): 670-83 Nephropedia Template TP {{tp|p=26474675|t=2015. Asymmetric cell division in T lymphocyte fate diversification |pdf=|usr=}}{{26474675}} gab.com Text Asymmetric cell division in T lymphocyte fate diversification JO: Trends Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26474675 #FOAvip Immunological protection against microbial pathogens is dependent on robust generation of functionally diverse T lymphocyte subsets. Upon microbial infection, naïve CD4+ or CD8+ T lymphocytes can give rise to effector- and memory-fated progeny that together mediate a potent immune response. Recent advances in single-cell immunological and genomic profiling technologies have helped elucidate early and late diversification mechanisms that enable the generation of heterogeneity from single T lymphocytes. We discuss these findings here and argue that one such mechanism, asymmetric cell division, creates an early divergence in T lymphocyte fates by giving rise to daughter cells with a propensity towards the terminally differentiated effector or self-renewing memory lineages, with cell-intrinsic and -extrinsic cues from the microenvironment driving the final maturation steps. Twit Text FOAVip Asymmetric cell division in T lymphocyte fate diversification ????Trends Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26474675 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26474675 #FOAvip English Wikipedia <ref>{{Cite pmid|26474675}}</ref> Asymmetric cell division in T lymphocyte fate diversification #MMPMID26474675 Arsenio J; Metz PJ; Chang JT Trends Immunol 2015[Nov]; 36 (11): 670-83 PMID26474675show ga Immunological protection against microbial pathogens is dependent on robust generation of functionally diverse T lymphocyte subsets. Upon microbial infection, naïve CD4+ or CD8+ T lymphocytes can give rise to effector- and memory-fated progeny that together mediate a potent immune response. Recent advances in single-cell immunological and genomic profiling technologies have helped elucidate early and late diversification mechanisms that enable the generation of heterogeneity from single T lymphocytes. We discuss these findings here and argue that one such mechanism, asymmetric cell division, creates an early divergence in T lymphocyte fates by giving rise to daughter cells with a propensity towards the terminally differentiated effector or self-renewing memory lineages, with cell-intrinsic and -extrinsic cues from the microenvironment driving the final maturation steps. äAsymmetric cell division in T lymphocyte fate diversification (epmc).pdf DeepDyve Pubget Overpricing