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10.1073/pnas.1519118112

http://scihub22266oqcxt.onion/10.1073/pnas.1519118112
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C4640754!4640754!26483497
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suck abstract from ncbi


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pmid26483497      Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (44): E6020-7
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  • Development of a diverse human T-cell repertoire despite stringent restriction of hematopoietic clonality in the thymus #MMPMID26483497
  • Brugman MH; Wiekmeijer AS; van Eggermond M; Wolvers-Tettero I; Langerak AW; de Haas EFE; Bystrykh LV; van Rood JJ; de Haan G; Fibbe WE; Staal FJT
  • Proc Natl Acad Sci U S A 2015[Nov]; 112 (44): E6020-7 PMID26483497show ga
  • The number of hematopoietic stem cell clones contributing to T-cell development is restricted at entry of and during further development inside the thymus. However, despite this severe restriction, a fully diverse T-cell receptor repertoire can be generated, indicating that hematological and immunological clonality are independently regulated.
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