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10.1038/jcbfm.2015.12 http://scihub22266oqcxt.onion/10.1038/jcbfm.2015.12 C4640247!4640247 !25669904     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25669904 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cereb+Blood+Flow+Metab 2015 ; 35 (6 ): 1005-14 Nephropedia Template TP {{tp|p=25669904 |t=2015. Gliovascular disruption and cognitive deficits in a mouse model with features of small vessel disease |pdf=|usr=}}{{25669904 }} gab.com Text Gliovascular disruption and cognitive deficits in a mouse model with features of small vessel disease JO: J Cereb Blood Flow Metab http://www.kidney.de/pget.php?&tw=1&pmid=25669904 #FOAvip Cerebral small vessel disease (SVD) is a major cause of age-related cognitive impairment and dementia. The pathophysiology of SVD is not well understood and is hampered by a limited range of relevant animal models. Here, we describe gliovascular alterations and cognitive deficits in a mouse model of sustained cerebral hypoperfusion with features of SVD (microinfarcts, hemorrhage, white matter disruption) induced by bilateral common carotid stenosis. Multiple features of SVD were determined on T2-weighted and diffusion-tensor magnetic resonance imaging scans and confirmed by pathologic assessment. These features, which were absent in sham controls, included multiple T2-hyperintense infarcts and T2-hypointense hemosiderin-like regions in subcortical nuclei plus increased cerebral atrophy compared with controls. Fractional anisotropy was also significantly reduced in several white matter structures including the corpus callosum. Investigation of gliovascular changes revealed a marked increase in microvessel diameter, vascular wall disruption, fibrinoid necrosis, hemorrhage, and blood-brain barrier alterations. Widespread reactive gliosis, including displacement of the astrocytic water channel, aquaporin 4, was observed. Hypoperfused mice also demonstrated deficits in spatial working and reference memory tasks. Overall, gliovascular disruption is a prominent feature of this mouse, which could provide a useful model for early-phase testing of potential SVD treatment strategies. Twit Text FOAVip Gliovascular disruption and cognitive deficits in a mouse model with features of small vessel disease ????J Cereb Blood Flow Metab http://www.kidney.de/pget.php?&tw=1&pmid=25669904 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25669904 #FOAvip English Wikipedia <ref>{{Cite pmid|25669904 }}</ref> Gliovascular disruption and cognitive deficits in a mouse model with features of small vessel disease #MMPMID25669904 Holland PR ; Searcy JL ; Salvadores N ; Scullion G ; Chen G ; Lawson G ; Scott F ; Bastin ME ; Ihara M ; Kalaria R ; Wood ER ; Smith C ; Wardlaw JM ; Horsburgh K J Cereb Blood Flow Metab 2015[Jun]; 35 (6 ): 1005-14 PMID25669904 show ga Cerebral small vessel disease (SVD) is a major cause of age-related cognitive impairment and dementia. The pathophysiology of SVD is not well understood and is hampered by a limited range of relevant animal models. Here, we describe gliovascular alterations and cognitive deficits in a mouse model of sustained cerebral hypoperfusion with features of SVD (microinfarcts, hemorrhage, white matter disruption) induced by bilateral common carotid stenosis. Multiple features of SVD were determined on T2-weighted and diffusion-tensor magnetic resonance imaging scans and confirmed by pathologic assessment. These features, which were absent in sham controls, included multiple T2-hyperintense infarcts and T2-hypointense hemosiderin-like regions in subcortical nuclei plus increased cerebral atrophy compared with controls. Fractional anisotropy was also significantly reduced in several white matter structures including the corpus callosum. Investigation of gliovascular changes revealed a marked increase in microvessel diameter, vascular wall disruption, fibrinoid necrosis, hemorrhage, and blood-brain barrier alterations. Widespread reactive gliosis, including displacement of the astrocytic water channel, aquaporin 4, was observed. Hypoperfused mice also demonstrated deficits in spatial working and reference memory tasks. Overall, gliovascular disruption is a prominent feature of this mouse, which could provide a useful model for early-phase testing of potential SVD treatment strategies. |Animals [MESH] |Atrophy/pathology [MESH] |Blood-Brain Barrier/pathology [MESH] |Brain/*pathology [MESH] |Cerebral Small Vessel Diseases/complications/*pathology [MESH] |Cognition [MESH] |Diffusion Tensor Imaging [MESH] |Disease Models, Animal [MESH] |Magnetic Resonance Imaging [MESH] |Male [MESH] |Mice, Inbred C57BL [MESH] |Microvessels/*pathology [MESH] |Neuroglia/pathology [MESH]Gliovascular disruption and cognitive deficits in a mouse model with f(epmc).pdf DeepDyve Pubget Overpricing