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10.1038/onc.2015.32 http://scihub22266oqcxt.onion/10.1038/onc.2015.32 C4640181!4640181!25728673     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncogene 2015 ; 34 (45): 5617-25 Nephropedia Template TP {{tp|p=25728673|t=2015. HSPB1 as a Novel Regulator of Ferroptotic Cancer Cell Death |pdf=|usr=}}{{25728673}} gab.com Text HSPB1 as a Novel Regulator of Ferroptotic Cancer Cell Death JO: Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=25728673 #FOAvip Ferroptosis is an iron-dependent form of non-apoptotic cell death, but its molecular mechanism remains largely unknown. Here, we demonstrate that heat shock protein beta-1 (HSPB1) is a negative regulator of ferroptotic cancer cell death. Erastin, a specific ferroptosis-inducing compound, stimulates heat shock factor 1 (HSF1)-dependent HSPB1 expression in cancer cells. Knockdown of HSF1 and HSPB1 enhances erastin-induced ferroptosis, whereas heat shock pretreatment and overexpression of HSPB1 inhibits erastin-induced ferroptosis. Protein kinase C-mediated HSPB1 phosphorylation confers protection against ferroptosis by reducing iron-mediated production of lipid reactive oxygen species. Moreover, inhibition of the HSF1-HSPB1 pathway and HSPB1 phosphorylation increases the anticancer activity of erastin in human xenograft mouse tumor models. Our findings reveal an essential role for HSPB1 in iron metabolism with important effects on ferroptosis-mediated cancer therapy. Twit Text FOAVip HSPB1 as a Novel Regulator of Ferroptotic Cancer Cell Death ????Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=25728673 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25728673 #FOAvip English Wikipedia <ref>{{Cite pmid|25728673}}</ref> HSPB1 as a Novel Regulator of Ferroptotic Cancer Cell Death #MMPMID25728673 Sun X; Ou Z; Xie M; Kang R; Fan Y; Niu X; Wang H; Cao L; Tang D Oncogene 2015[Nov]; 34 (45): 5617-25 PMID25728673show ga Ferroptosis is an iron-dependent form of non-apoptotic cell death, but its molecular mechanism remains largely unknown. Here, we demonstrate that heat shock protein beta-1 (HSPB1) is a negative regulator of ferroptotic cancer cell death. Erastin, a specific ferroptosis-inducing compound, stimulates heat shock factor 1 (HSF1)-dependent HSPB1 expression in cancer cells. Knockdown of HSF1 and HSPB1 enhances erastin-induced ferroptosis, whereas heat shock pretreatment and overexpression of HSPB1 inhibits erastin-induced ferroptosis. Protein kinase C-mediated HSPB1 phosphorylation confers protection against ferroptosis by reducing iron-mediated production of lipid reactive oxygen species. Moreover, inhibition of the HSF1-HSPB1 pathway and HSPB1 phosphorylation increases the anticancer activity of erastin in human xenograft mouse tumor models. Our findings reveal an essential role for HSPB1 in iron metabolism with important effects on ferroptosis-mediated cancer therapy. äHSPB1 as a Novel Regulator of Ferroptotic Cancer Cell Death (epmc).pdf DeepDyve Pubget Overpricing