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10.1172/JCI84753 http://scihub22266oqcxt.onion/10.1172/JCI84753 C4639952!4639952!26495835     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest ä ; 125 (11): 4008-10 Nephropedia Template TP {{tp|p=26495835|t=ä. Skin tight: macrophage-specific COX-2 induction links salt handling in kidney and skin |pdf=|usr=}}{{26495835}} gab.com Text Skin tight: macrophage-specific COX-2 induction links salt handling in kidney and skin JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=26495835 #FOAvip The relationship between dietary salt intake and the associated risk of hypertension and cardiovascular disease is an important public health concern. In this issue of the JCI, a study by Zhang and associates shows that consumption of a high-sodium diet induces expression of cyclooxygenase-2 (COX-2) in macrophages, resulting in enhanced levels of prostaglandin E2 (PGE2), autocrine activation of the macrophage E-prostanoid 4 (EP4) receptor, and subsequent triggering of parallel pathways in the kidney and in skin that help dispose of excess sodium. The authors found that blockade or genetic elimination of the COX-2/PGE2/EP4 receptor pathway in hematopoietic cells causes salt-sensitive hypertension in mice. These studies illuminate an unexpected central role for the macrophage in coordinating homeostatic responses to dietary salt intake and suggest a complex pathophysiology for hypertension associated with NSAID use. Twit Text FOAVip Skin tight: macrophage-specific COX-2 induction links salt handling in kidney and skin ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=26495835 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26495835 #FOAvip English Wikipedia <ref>{{Cite pmid|26495835}}</ref> Skin tight: macrophage-specific COX-2 induction links salt handling in kidney and skin #MMPMID26495835 Stegbauer J; Coffman TM J Clin Invest ä[]; 125 (11): 4008-10 PMID26495835show ga The relationship between dietary salt intake and the associated risk of hypertension and cardiovascular disease is an important public health concern. In this issue of the JCI, a study by Zhang and associates shows that consumption of a high-sodium diet induces expression of cyclooxygenase-2 (COX-2) in macrophages, resulting in enhanced levels of prostaglandin E2 (PGE2), autocrine activation of the macrophage E-prostanoid 4 (EP4) receptor, and subsequent triggering of parallel pathways in the kidney and in skin that help dispose of excess sodium. The authors found that blockade or genetic elimination of the COX-2/PGE2/EP4 receptor pathway in hematopoietic cells causes salt-sensitive hypertension in mice. These studies illuminate an unexpected central role for the macrophage in coordinating homeostatic responses to dietary salt intake and suggest a complex pathophysiology for hypertension associated with NSAID use. äSkin tight: macrophage-specific COX-2 induction links salt handling in(epmc).pdf DeepDyve Pubget Overpricing