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10.1038/srep16386 http://scihub22266oqcxt.onion/10.1038/srep16386 C4639835!4639835 !26552368     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26552368 &cmd=llinks): Failed to open stream: HTTP request failed! 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Resveratrol inhibits epithelial-mesenchymal transition of retinal pigment epithelium and development of proliferative vitreoretinopathy |pdf=|usr=}}{{26552368 }} gab.com Text Resveratrol inhibits epithelial-mesenchymal transition of retinal pigment epithelium and development of proliferative vitreoretinopathy JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26552368 #FOAvip Proliferative vitreoretinopathy (PVR) is a serious complication of retinal detachment and ocular trauma, and its recurrence may lead to irreversible vision loss. Epithelial to mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells is a critical step in the pathogenesis of PVR, which is characterized by fibrotic membrane formation and traction retinal detachment. In this study, we investigated the potential impact of resveratrol (RESV) on EMT and the fibrotic process in cultured RPE cells and further examined the preventive effect of RESV on PVR development using a rabbit model of PVR. We found that RESV induces mesenchymal to epithelial transition (MET) and inhibits transforming growth factor-?2(TGF-?2)-induced EMT of RPE cells by deacetylating SMAD4. The effect of RESV on MET was dependent on sirtuin1 activation. RESV suppressed proliferation, migration and fibronectin synthesis induced by platelet-derived growth factor-BB or TGF-?2. In vivo, RESV inhibited the progression of experimental PVR in rabbit eyes. Histological findings showed that RESV reduced fibrotic membrane formation and decreased ?-SMA expression in the epiretinal membranes. These results suggest the potential use of RESV as a therapeutic agent to prevent the development of PVR by targeting EMT of RPE. Twit Text FOAVip Resveratrol inhibits epithelial-mesenchymal transition of retinal pigment epithelium and development of proliferative vitreoretinopathy ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26552368 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26552368 #FOAvip English Wikipedia <ref>{{Cite pmid|26552368 }}</ref> Resveratrol inhibits epithelial-mesenchymal transition of retinal pigment epithelium and development of proliferative vitreoretinopathy #MMPMID26552368 Ishikawa K ; He S ; Terasaki H ; Nazari H ; Zhang H ; Spee C ; Kannan R ; Hinton DR Sci Rep 2015[Nov]; 5 (ä): 16386 PMID26552368 show ga Proliferative vitreoretinopathy (PVR) is a serious complication of retinal detachment and ocular trauma, and its recurrence may lead to irreversible vision loss. Epithelial to mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells is a critical step in the pathogenesis of PVR, which is characterized by fibrotic membrane formation and traction retinal detachment. In this study, we investigated the potential impact of resveratrol (RESV) on EMT and the fibrotic process in cultured RPE cells and further examined the preventive effect of RESV on PVR development using a rabbit model of PVR. We found that RESV induces mesenchymal to epithelial transition (MET) and inhibits transforming growth factor-?2(TGF-?2)-induced EMT of RPE cells by deacetylating SMAD4. The effect of RESV on MET was dependent on sirtuin1 activation. RESV suppressed proliferation, migration and fibronectin synthesis induced by platelet-derived growth factor-BB or TGF-?2. In vivo, RESV inhibited the progression of experimental PVR in rabbit eyes. Histological findings showed that RESV reduced fibrotic membrane formation and decreased ?-SMA expression in the epiretinal membranes. These results suggest the potential use of RESV as a therapeutic agent to prevent the development of PVR by targeting EMT of RPE. |Acetylation [MESH] |Animals [MESH] |Biomarkers [MESH] |Cell Movement/drug effects [MESH] |Cell Proliferation/drug effects [MESH] |Disease Models, Animal [MESH] |Disease Progression [MESH] |Epithelial Cells/drug effects/metabolism/pathology [MESH] |Epithelial-Mesenchymal Transition/*drug effects [MESH] |Fibronectins/biosynthesis [MESH] |Rabbits [MESH] |Resveratrol [MESH] |Retinal Pigment Epithelium/*drug effects/metabolism/*pathology [MESH] |Sirtuin 1/metabolism [MESH] |Smad4 Protein/metabolism [MESH] |Stilbenes/*pharmacology [MESH] |Transforming Growth Factor beta2/metabolism [MESH]Resveratrol inhibits epithelial-mesenchymal transition of retinal pigm(epmc).pdf DeepDyve Pubget Overpricing