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10.1038/srep16226 http://scihub22266oqcxt.onion/10.1038/srep16226 C4639770!4639770 !26552961     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26552961 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2015 ; 5 (ä): 16226 Nephropedia Template TP {{tp|p=26552961 |t=2015. Green tea inhibited the elimination of nephro-cardiovascular toxins and deteriorated the renal function in rats with renal failure |pdf=|usr=}}{{26552961 }} gab.com Text Green tea inhibited the elimination of nephro-cardiovascular toxins and deteriorated the renal function in rats with renal failure JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26552961 #FOAvip Chronic kidney disease (CKD) is a major health problem worldwide. Indoxyl sulfate (IS) and p-cresyl sulfate (PCS) are highly protein-bound nephro-cardiovascular toxins, which are not efficiently removed through hemodialysis. The renal excretions of IS and PCS were mediated by organic anion transporters (OATs) such as OAT1 and OAT3. Green tea (GT) is a popular beverage containing plenty of catechins. Previous pharmacokinetic studies of teas have shown that the major molecules present in the bloodstream are the glucuronides/sulfates of tea catechins, which are putative substrates of OATs. Here we demonstrated that GT ingestion significantly elevated the systemic exposures of endogenous IS and PCS in rats with chronic renal failure (CRF). More importantly, GT also significantly increased the levels of serum creatinine (Cr) and blood urea nitrogen (BUN) in CRF rats. Mechanism studies indicated that the serum metabolites of GT (GTM) inhibited the uptake transporting functions of OAT1 and OAT3. In conclusion, GT inhibited the elimination of nephro-cardiovascular toxins such as IS and PCS, and deteriorated the renal function in CRF rats. Twit Text FOAVip Green tea inhibited the elimination of nephro-cardiovascular toxins and deteriorated the renal function in rats with renal failure ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26552961 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26552961 #FOAvip English Wikipedia <ref>{{Cite pmid|26552961 }}</ref> Green tea inhibited the elimination of nephro-cardiovascular toxins and deteriorated the renal function in rats with renal failure #MMPMID26552961 Peng YH ; Sweet DH ; Lin SP ; Yu CP ; Lee Chao PD ; Hou YC Sci Rep 2015[Nov]; 5 (ä): 16226 PMID26552961 show ga Chronic kidney disease (CKD) is a major health problem worldwide. Indoxyl sulfate (IS) and p-cresyl sulfate (PCS) are highly protein-bound nephro-cardiovascular toxins, which are not efficiently removed through hemodialysis. The renal excretions of IS and PCS were mediated by organic anion transporters (OATs) such as OAT1 and OAT3. Green tea (GT) is a popular beverage containing plenty of catechins. Previous pharmacokinetic studies of teas have shown that the major molecules present in the bloodstream are the glucuronides/sulfates of tea catechins, which are putative substrates of OATs. Here we demonstrated that GT ingestion significantly elevated the systemic exposures of endogenous IS and PCS in rats with chronic renal failure (CRF). More importantly, GT also significantly increased the levels of serum creatinine (Cr) and blood urea nitrogen (BUN) in CRF rats. Mechanism studies indicated that the serum metabolites of GT (GTM) inhibited the uptake transporting functions of OAT1 and OAT3. In conclusion, GT inhibited the elimination of nephro-cardiovascular toxins such as IS and PCS, and deteriorated the renal function in CRF rats. |Adenine/pharmacology [MESH] |Animals [MESH] |CHO Cells [MESH] |Catechin/analysis/pharmacology [MESH] |Creatinine/blood [MESH] |Cresols/blood/pharmacokinetics [MESH] |Cricetinae [MESH] |Cricetulus [MESH] |Disease Models, Animal [MESH] |Glucuronides/chemistry [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Indican/blood/pharmacokinetics [MESH] |Kidney/drug effects/metabolism [MESH] |Male [MESH] |Organic Anion Transport Protein 1/genetics/metabolism [MESH] |Organic Anion Transporters, Sodium-Independent/genetics/metabolism [MESH] |Rats [MESH] |Rats, Sprague-Dawley [MESH] |Renal Insufficiency/metabolism/pathology [MESH] |Sulfates/chemistry [MESH] |Sulfuric Acid Esters/blood/pharmacokinetics [MESH] |Tea/*chemistry/metabolism [MESH]Green tea inhibited the elimination of nephro-cardiovascular toxins an(epmc).pdf DeepDyve Pubget Overpricing