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10.3389/fimmu.2015.00570 http://scihub22266oqcxt.onion/10.3389/fimmu.2015.00570 C4639612!4639612!26617605     free     free     free       Front+Immunol 2015 ; 6 (ä): ä Nephropedia Template TP {{tp|p=26617605|t=2015. Bacterial Exotoxins and the Inflammasome |pdf=|usr=}}{{26617605}} gab.com Text Bacterial Exotoxins and the Inflammasome JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26617605 #FOAvip The inflammasomes are intracellular protein complexes that play an important role in innate immune sensing. Activation of inflammasomes leads to activation of caspase-1 and maturation and secretion of the pro-inflammatory cytokines interleukin (IL)-1? and IL-18. In certain myeloid cells, this activation can also lead to an inflammatory cell death (pyroptosis). Inflammasome sensor proteins have evolved to detect a range of microbial ligands and bacterial exotoxins either through direct interaction or by detection of host cell changes elicited by these effectors. Bacterial exotoxins activate the inflammasomes through diverse processes, including direct sensor cleavage, modulation of ion fluxes through plasma membrane pore formation, and perturbation of various host cell functions. In this review, we summarize the findings on some of the bacterial exotoxins that activate the inflammasomes. Twit Text FOAVip Bacterial Exotoxins and the Inflammasome ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26617605 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26617605 #FOAvip English Wikipedia <ref>{{Cite pmid|26617605}}</ref> Bacterial Exotoxins and the Inflammasome #MMPMID26617605 Greaney AJ; Leppla SH; Moayeri M Front Immunol 2015[]; 6 (ä): ä PMID26617605show ga The inflammasomes are intracellular protein complexes that play an important role in innate immune sensing. Activation of inflammasomes leads to activation of caspase-1 and maturation and secretion of the pro-inflammatory cytokines interleukin (IL)-1? and IL-18. In certain myeloid cells, this activation can also lead to an inflammatory cell death (pyroptosis). Inflammasome sensor proteins have evolved to detect a range of microbial ligands and bacterial exotoxins either through direct interaction or by detection of host cell changes elicited by these effectors. Bacterial exotoxins activate the inflammasomes through diverse processes, including direct sensor cleavage, modulation of ion fluxes through plasma membrane pore formation, and perturbation of various host cell functions. In this review, we summarize the findings on some of the bacterial exotoxins that activate the inflammasomes. äBacterial Exotoxins and the Inflammasome (epmc).pdf DeepDyve Pubget Overpricing