Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.jaci.2015.04.001 http://scihub22266oqcxt.onion/10.1016/j.jaci.2015.04.001 C4639468!4639468!25962902     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Allergy+Clin+Immunol 2015 ; 136 (5): 1387-1397.e7 Nephropedia Template TP {{tp|p=25962902|t=2015. Skin DC Induce Follicular Helper T Cells and Protective Humoral Immune Responses |pdf=|usr=}}{{25962902}} gab.com Text Skin DC Induce Follicular Helper T Cells and Protective Humoral Immune Responses JO: J Allergy Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25962902 #FOAvip Background: The contribution of individual subsets of dendritic cells (DC) to the generation of adaptive immunity is central to understanding immune homeostasis and protective immune responses. Objective: We sought to define functions for steady-state skin DC. Methods: Herein we present an approach in which we restrict antigen presentation to individual DC subsets in the skin and monitor the effects on endogenous antigen-specific CD4+ T and B cell responses. Results: Presentation of foreign antigen by Langerhans cells (LC) in the absence of exogenous adjuvant led to a large expansion of T follicular helper cells (Tfh). This was accompanied by B cell activation, germinal center formation and protective antibody responses against influenza. The expansion of Tfh and antibody responses could be elicited by both systemic and topical skin immunization. Tfh induction was not restricted to LC and occurred in response to antigen presentation by CD103+ dermal DC. CD103+ DC despite inducing similar Tfh responses as LC, were less efficient in induction of GC B cells and humoral immune responses. We also found that skin DC are sufficient to expand CXCR5+ Tfh through an IL-6 and IFNAR independent mechanism, but B cells were required for sustained Bcl6+ expression. Conclusions: These data demonstrate that a major unappreciated function of skin DC is their promotion of Tfh and humoral immune responses that potentially represent an efficient approach for vaccination. Clinical Implications: Our findings suggest that targeting antigen without adjuvants to a specific skin DC subset either by systemic or topical application will be an efficient approach to generate protective, antibody-based vaccines. Twit Text FOAVip Skin DC Induce Follicular Helper T Cells and Protective Humoral Immune Responses ????J Allergy Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25962902 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25962902 #FOAvip English Wikipedia <ref>{{Cite pmid|25962902}}</ref> Skin DC Induce Follicular Helper T Cells and Protective Humoral Immune Responses #MMPMID25962902 Yao C; Zurawski SM; Jarrett ES; Chicoine B; Crabtree J; Peterson EJ; Zurawski G; Kaplan DH; Igyártó BZ J Allergy Clin Immunol 2015[Nov]; 136 (5): 1387-1397.e7 PMID25962902show ga Background: The contribution of individual subsets of dendritic cells (DC) to the generation of adaptive immunity is central to understanding immune homeostasis and protective immune responses. Objective: We sought to define functions for steady-state skin DC. Methods: Herein we present an approach in which we restrict antigen presentation to individual DC subsets in the skin and monitor the effects on endogenous antigen-specific CD4+ T and B cell responses. Results: Presentation of foreign antigen by Langerhans cells (LC) in the absence of exogenous adjuvant led to a large expansion of T follicular helper cells (Tfh). This was accompanied by B cell activation, germinal center formation and protective antibody responses against influenza. The expansion of Tfh and antibody responses could be elicited by both systemic and topical skin immunization. Tfh induction was not restricted to LC and occurred in response to antigen presentation by CD103+ dermal DC. CD103+ DC despite inducing similar Tfh responses as LC, were less efficient in induction of GC B cells and humoral immune responses. We also found that skin DC are sufficient to expand CXCR5+ Tfh through an IL-6 and IFNAR independent mechanism, but B cells were required for sustained Bcl6+ expression. Conclusions: These data demonstrate that a major unappreciated function of skin DC is their promotion of Tfh and humoral immune responses that potentially represent an efficient approach for vaccination. Clinical Implications: Our findings suggest that targeting antigen without adjuvants to a specific skin DC subset either by systemic or topical application will be an efficient approach to generate protective, antibody-based vaccines. äSkin DC Induce Follicular Helper T Cells and Protective Humoral Immune(epmc).pdf DeepDyve Pubget Overpricing