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10.1016/j.cct.2015.06.007

http://scihub22266oqcxt.onion/10.1016/j.cct.2015.06.007
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C4639447!4639447!26079372
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suck abstract from ncbi


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pmid26079372      Contemp+Clin+Trials 2015 ; 45 (0 0): 93-102
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  • Adaptive Design of Confirmatory Trials: Advances and Challenges #MMPMID26079372
  • Lai TL; Lavori PW; Tsang KW
  • Contemp Clin Trials 2015[Nov]; 45 (0 0): 93-102 PMID26079372show ga
  • The past decade witnessed major developments in innovative designs of confirmatory clinical trials, and adaptive designs represent the most active area of these developments. We give an overview of the developments and associated statistical methods in several classes of adaptive designs of confirmatory trials. We also discuss their statistical difficulties and implementation challenges, and show how these problems are connected to other branches of mainstream Statistics, which we then apply to resolve the difficulties and bypass the bottlenecks in the development of adaptive designs for the next decade.
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