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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Trends+Genet 2015 ; 31 (11): 613-26 Nephropedia Template TP
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microRNA nomenclature: A view incorporating genetic origins, biosynthetic pathways, and sequence variants #MMPMID26453491
Trends Genet 2015[Nov]; 31 (11): 613-26 PMID26453491show ga
High-throughput sequencing of microRNAs has revealed the diversity and variability of mature and functional short non-coding RNAs, including their genomic origins, biogenesis pathways, sequence variability, and newly identified products, such as microRNA-offset RNAs. Here, we review known cases of alternative mature miRNA-like RNA fragments and propose a revised definition of microRNAs to encompass this diversity. We then review nomenclature guidelines for microRNAs and propose to extend nomenclature conventions to align with those for protein-coding genes established by international consortia. Finally, we suggest a system to encompass the full complexity of sequence variations, i.e. isomiRs, in the analysis of small RNA sequencing experiments.