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10.1016/j.tig.2015.09.002

http://scihub22266oqcxt.onion/10.1016/j.tig.2015.09.002
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C4639415!4639415!26453491
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suck abstract from ncbi


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pmid26453491      Trends+Genet 2015 ; 31 (11): 613-26
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  • microRNA nomenclature: A view incorporating genetic origins, biosynthetic pathways, and sequence variants #MMPMID26453491
  • Desvignes T; Batzel P; Berezikov E; Eilbeck K; Eppig J; McAndrews M; Singer A; Postlethwait J
  • Trends Genet 2015[Nov]; 31 (11): 613-26 PMID26453491show ga
  • High-throughput sequencing of microRNAs has revealed the diversity and variability of mature and functional short non-coding RNAs, including their genomic origins, biogenesis pathways, sequence variability, and newly identified products, such as microRNA-offset RNAs. Here, we review known cases of alternative mature miRNA-like RNA fragments and propose a revised definition of microRNAs to encompass this diversity. We then review nomenclature guidelines for microRNAs and propose to extend nomenclature conventions to align with those for protein-coding genes established by international consortia. Finally, we suggest a system to encompass the full complexity of sequence variations, i.e. isomiRs, in the analysis of small RNA sequencing experiments.
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