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10.1016/j.tig.2015.09.002

http://scihub22266oqcxt.onion/10.1016/j.tig.2015.09.002
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suck abstract from ncbi


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pmid26453491
      Trends+Genet 2015 ; 31 (11 ): 613-626
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  • miRNA Nomenclature: A View Incorporating Genetic Origins, Biosynthetic Pathways, and Sequence Variants #MMPMID26453491
  • Desvignes T ; Batzel P ; Berezikov E ; Eilbeck K ; Eppig JT ; McAndrews MS ; Singer A ; Postlethwait JH
  • Trends Genet 2015[Nov]; 31 (11 ): 613-626 PMID26453491 show ga
  • High-throughput sequencing of miRNAs has revealed the diversity and variability of mature and functional short noncoding RNAs, including their genomic origins, biogenesis pathways, sequence variability, and newly identified products such as miRNA-offset RNAs (moRs). Here we review known cases of alternative mature miRNA-like RNA fragments and propose a revised definition of miRNAs to encompass this diversity. We then review nomenclature guidelines for miRNAs and propose to extend nomenclature conventions to align with those for protein-coding genes established by international consortia. Finally, we suggest a system to encompass the full complexity of sequence variations (i.e., isomiRs) in the analysis of small RNA sequencing experiments.
  • |*Genetic Variation [MESH]
  • |*Terminology as Topic [MESH]
  • |Animals [MESH]
  • |Biosynthetic Pathways/*genetics [MESH]
  • |DEAD-box RNA Helicases/genetics/metabolism [MESH]
  • |Gene Expression Regulation [MESH]
  • |Humans [MESH]
  • |Mice [MESH]
  • |MicroRNAs/*classification/*genetics/metabolism [MESH]
  • |RNA, Small Cytoplasmic/genetics/metabolism [MESH]
  • |RNA, Small Interfering/genetics/metabolism [MESH]
  • |Ribonuclease III/genetics/metabolism [MESH]
  • |Sequence Analysis, RNA [MESH]
  • |Transcriptome [MESH]


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