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Novel Etoposide Analogue Modulates Expression of Angiogenesis Associated
microRNAs and Regulates Cell Proliferation by Targeting STAT3 in Breast Cancer
#MMPMID26551008
Srinivas C
; Ramaiah MJ
; Lavanya A
; Yerramsetty S
; Kavi Kishor PB
; Basha SA
; Kamal A
; Bhadra U
; Bhadra MP
PLoS One
2015[]; 10
(11
): e0142006
PMID26551008
show ga
Tumor microenvironment play role in angiogenesis and carcinogenesis. Etoposide, a
known topoisomerase II inhibitor induces DNA damage resulting in cell cycle
arrest. We developed a novel Etoposide analogue,
Quinazolino-4?-amidopodophyllotoxin (C-10) that show better efficacy in
regulating cell proliferation and angiogenesis. We evaluated its role on
expression of microRNAs-15, 16, 17 and 221 and its targets Bcl-2, STAT3 and VEGF
that dictate cell proliferation and angiogenesis. Docking studies clearly
demonstrated the binding of Etoposide and C-10 to STAT3. We conclude that
combination of Etoposide or C-10 with miR-15, 16, 17 and 221 as a new approach to
induce apoptosis and control angiogenesis in breast cancer.
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