The Sin1 PH domain connects mTORC2 to PI3K #MMPMID26526694
Yuan HX; Guan KL
Cancer Discov 2015[Nov]; 5 (11): 1127-9 PMID26526694show ga
The mechanistic target of rapamycin (mTOR) complex 2, mTORC2, is a critical downstream effector of PI3K to stimulate AGC kinase members, including Akt, PKC, and SGK. Liu et al reported that the PH domain of Sin1, an essential component of mTORC2, directly binds the PI3K product PtdIns(3,4,5)P3 to promote mTORC2 kinase activation and membrane localization, thereby revealing a mechanistic link between PI3K and mTORC2.