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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Adv+Biomed+Res
2015 ; 4
(ä): 227
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Effect of cholecystokinin on learning and memory, neuronal proliferation and
apoptosis in the rat hippocampus
#MMPMID26623402
Reisi P
; Ghaedamini AR
; Golbidi M
; Shabrang M
; Arabpoor Z
; Rashidi B
Adv Biomed Res
2015[]; 4
(ä): 227
PMID26623402
show ga
BACKGROUND: Cholecystokinin (CCK) has roles in learning and memory, but the
cellular mechanism is poorly understood. This study investigated the effect of
CCK on spatial learning and memory, neuronal proliferation and apoptosis in the
hippocampus in rats. MATERIALS AND METHODS: Experimental groups were control and
CCK. The rats received CKK octapeptide sulfated (CCK-8S, 1.6 ?g/kg, i.p.) for 14
days. Spatial learning and memory were tested by Morris water maze and finally
immunohistochemical study was performed; neurogenesis by Ki-67 method and
apoptosis by Terminal deoxynucleotidyl transferase mediated dUTP Nick End
Labeling (TUNEL) assay in hippocampal dentate gyrus (DG). RESULTS:
Cholecystokinin increased Ki-67 positive cells and reduced TUNEL positive cells
in the granular layer of hippocampal DG. CCK failed to have a significant effect
on spatial learning and memory. CONCLUSION: Results indicate neuroprotective and
proliferative effects of CCK in the hippocampus; however, other factors are
probably involved until the newly born neurons achieve necessary integrity for
behavioral changes.