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2015 ; 19
(10
): 621-3
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gab.com Text
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English Wikipedia
A rare case of idiopathic cluster of differentiation 4(+) T-cell lymphocytopenia
presenting with disseminated tubercular infection
#MMPMID26628830
Sikri V
; Kaur H
; Jain A
Indian J Crit Care Med
2015[Oct]; 19
(10
): 621-3
PMID26628830
show ga
Idiopathic cluster of differentiation 4(+) (CD4(+)) T-cell lymphocytopenia is a
rare heterogeneous clinical syndrome characterized by low absolute CD4 counts on
two different occasions without any evidence of other known cause of
immunodeficiency including human immunodeficiency virus (HIV), infections or
drugs associated with fall in CD4(+) count. Also referred to as severe
unexplained HIV seronegative immune suppression by the World Health Organization,
it was first described by Centers for Disease Control in 1992 in patients with
opportunistic infections who were negative for HIV but had low CD4 counts.
Patients typically present with opportunistic infections, malignancies, or
autoimmune disorders. There have been case reports on opportunistic infections
such as cryptococcal meningitis or non-Mycobacterium tuberculosis infections in
these patients. However, no case of disseminated M. tuberculosis has been
reported as such in Indian literature. We present a case of disseminated
tuberculosis with low CD4 counts without any evidence of HIV infection.