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10.1038/srep16513 http://scihub22266oqcxt.onion/10.1038/srep16513 C4637888!4637888 !26549353     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26549353 &cmd=llinks): Failed to open stream: HTTP request failed! 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A novel function of the human oncogene Stil: Regulation of PC12 cell toxic susceptibility through the Shh pathway |pdf=|usr=}}{{26549353 }} gab.com Text A novel function of the human oncogene Stil: Regulation of PC12 cell toxic susceptibility through the Shh pathway JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26549353 #FOAvip The human oncogene SCL/TAL1 interrupting locus (Stil) is highly conserved in vertebrate species. Here, we report new findings of Stil in the regulation of toxic susceptibility in mammalian dopaminergic (DA)-like PC12 cells. RNAi-mediated knockdown of Stil expression did not affect the survival of proliferating PC12 cells but caused a significant amount of cell death in differentiated neurons after toxic drug treatment. In contrast, overexpression of Stil increased toxic susceptibility only in proliferating cells but produced no effect in mature neurons. Exogenetic inactivation or activation of the Sonic hedgehog (Shh) signaling transduction mimicked the effect of Stil knockdown or overexpression in regulation of PC12 cell toxic susceptibility, suggesting that Stil exerts its role through the Shh pathway. Together, the data provide evidence for novel functions of the human oncogene Stil in neural toxic susceptibility. Twit Text FOAVip A novel function of the human oncogene Stil: Regulation of PC12 cell toxic susceptibility through the Shh pathway ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26549353 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26549353 #FOAvip English Wikipedia <ref>{{Cite pmid|26549353 }}</ref> A novel function of the human oncogene Stil: Regulation of PC12 cell toxic susceptibility through the Shh pathway #MMPMID26549353 Li L ; Carr AL ; Sun L ; Drewing A ; Lee J ; Rao Z Sci Rep 2015[Nov]; 5 (ä): 16513 PMID26549353 show ga The human oncogene SCL/TAL1 interrupting locus (Stil) is highly conserved in vertebrate species. Here, we report new findings of Stil in the regulation of toxic susceptibility in mammalian dopaminergic (DA)-like PC12 cells. RNAi-mediated knockdown of Stil expression did not affect the survival of proliferating PC12 cells but caused a significant amount of cell death in differentiated neurons after toxic drug treatment. In contrast, overexpression of Stil increased toxic susceptibility only in proliferating cells but produced no effect in mature neurons. Exogenetic inactivation or activation of the Sonic hedgehog (Shh) signaling transduction mimicked the effect of Stil knockdown or overexpression in regulation of PC12 cell toxic susceptibility, suggesting that Stil exerts its role through the Shh pathway. Together, the data provide evidence for novel functions of the human oncogene Stil in neural toxic susceptibility. |*Oncogenes [MESH] |*Signal Transduction [MESH] |Animals [MESH] |Apoptosis/drug effects/genetics [MESH] |Caspase 3/metabolism [MESH] |Cell Survival/drug effects [MESH] |Drug Resistance/*genetics [MESH] |Gene Expression [MESH] |Hedgehog Proteins/*metabolism [MESH] |Humans [MESH] |Intracellular Signaling Peptides and Proteins/*genetics/*metabolism [MESH] |Neurotoxins/toxicity [MESH] |Oxidopamine/toxicity [MESH] |PC12 Cells [MESH]A novel function of the human oncogene Stil: Regulation of PC12 cell t(epmc).pdf DeepDyve Pubget Overpricing