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10.1177/1759720X15601805 http://scihub22266oqcxt.onion/10.1177/1759720X15601805 C4637847!4637847!26622325     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Ther+Adv+Musculoskelet+Dis 2015 ; 7 (6): 234-46 Nephropedia Template TP {{tp|p=26622325|t=2015. Key issues in the management of patients with systemic lupus erythematosus: latest developments and clinical implications |pdf=|usr=}}{{26622325}} gab.com Text Key issues in the management of patients with systemic lupus erythematosus: latest developments and clinical implications JO: Ther Adv Musculoskelet Dis http://www.kidney.de/pget.php?&tw=1&pmid=26622325 #FOAvip Systemic lupus erythematous (SLE) is a chronic multisystem disease with significant associated morbidity and mortality. A deeper understanding of the pathogenesis of SLE has led to the development of biologic agents, primarily targeting B cells and others inhibiting costimulatory molecules, type I interferons and cytokines such as interleukin-6. Several of these agents have been studied in clinical trials; some have shown promise while others have yielded disappointing results. Economic and regulatory issues continue to hamper the availability of such therapies for SLE patients. With increasing recognition that recurrent flares of disease activity lead to long-term damage accrual, one of the most important recent developments in patient management has been the concept of treat-to-target in SLE while minimizing patient exposure to excessive corticosteroid and other immunosuppressive therapy. This article reviews these key issues in SLE management, outlining recent developments and clinical implications for patients. Twit Text FOAVip Key issues in the management of patients with systemic lupus erythematosus: latest developments and clinical implications ????Ther Adv Musculoskelet Dis http://www.kidney.de/pget.php?&tw=1&pmid=26622325 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26622325 #FOAvip English Wikipedia <ref>{{Cite pmid|26622325}}</ref> Key issues in the management of patients with systemic lupus erythematosus: latest developments and clinical implications #MMPMID26622325 Jordan N; D?Cruz D Ther Adv Musculoskelet Dis 2015[Dec]; 7 (6): 234-46 PMID26622325show ga Systemic lupus erythematous (SLE) is a chronic multisystem disease with significant associated morbidity and mortality. A deeper understanding of the pathogenesis of SLE has led to the development of biologic agents, primarily targeting B cells and others inhibiting costimulatory molecules, type I interferons and cytokines such as interleukin-6. Several of these agents have been studied in clinical trials; some have shown promise while others have yielded disappointing results. Economic and regulatory issues continue to hamper the availability of such therapies for SLE patients. With increasing recognition that recurrent flares of disease activity lead to long-term damage accrual, one of the most important recent developments in patient management has been the concept of treat-to-target in SLE while minimizing patient exposure to excessive corticosteroid and other immunosuppressive therapy. This article reviews these key issues in SLE management, outlining recent developments and clinical implications for patients. äKey issues in the management of patients with systemic lupus erythemat(epmc).pdf DeepDyve Pubget Overpricing