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http://scihub22266oqcxt.onion/ C4637768!4637768!26617952     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Clin+Exp+Pathol 2015 ; 8 (9): 11945 Nephropedia Template TP {{tp|p=26617952|t=2015. Signaling pathway and molecular subgroups of medulloblastoma |pdf=|usr=}}{{26617952}} gab.com Text Signaling pathway and molecular subgroups of medulloblastoma JO: Int J Clin Exp Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26617952 #FOAvip Medulloblastoma (MB) is the most common malignant brain tumor in children. Although multimodality treatment regimens including surgery, radiotherapy and chemotherapy have greatly improved disease outcome, about one-third of MB patient remains incurable, and many long-term survivors are suffered from deleterious effects due to aggressive treatment. Understanding the signaling pathways and the genetic mechanisms contributed to MB development would be the key to develop novel therapeutic treatment strategies for improving survival and outcome of MB. In this review, we discuss the biological signaling pathways involved in MB pathogenesis. We also go through the current international consensus of four core MB subgroups namely, SHH, WNT, Group 3 and Group 4. This is adopted based on the knowledge of genomic complexity of MB as analyzed by recent high-throughput genomic technology. We talk about immunohistochemistry assays established to determine molecular subgroup affiliation. In the last part of review, we discuss how identification of molecular subgroups is going to change our routine disease diagnosis and clinical management. Twit Text FOAVip Signaling pathway and molecular subgroups of medulloblastoma ????Int J Clin Exp Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26617952 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26617952 #FOAvip English Wikipedia <ref>{{Cite pmid|26617952}}</ref> Signaling pathway and molecular subgroups of medulloblastoma #MMPMID26617952 Li KKW; Lau KM; Ng HK Int J Clin Exp Pathol 2015[]; 8 (9): 11945 PMID26617952show ga Medulloblastoma (MB) is the most common malignant brain tumor in children. Although multimodality treatment regimens including surgery, radiotherapy and chemotherapy have greatly improved disease outcome, about one-third of MB patient remains incurable, and many long-term survivors are suffered from deleterious effects due to aggressive treatment. Understanding the signaling pathways and the genetic mechanisms contributed to MB development would be the key to develop novel therapeutic treatment strategies for improving survival and outcome of MB. In this review, we discuss the biological signaling pathways involved in MB pathogenesis. We also go through the current international consensus of four core MB subgroups namely, SHH, WNT, Group 3 and Group 4. This is adopted based on the knowledge of genomic complexity of MB as analyzed by recent high-throughput genomic technology. We talk about immunohistochemistry assays established to determine molecular subgroup affiliation. In the last part of review, we discuss how identification of molecular subgroups is going to change our routine disease diagnosis and clinical management. äSignaling pathway and molecular subgroups of medulloblastoma (epmc).pdf DeepDyve Pubget Overpricing