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pmid26617856      Int+J+Clin+Exp+Pathol 2015 ; 8 (9): 11323-31
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  • Differences in peritumoral pseudocapsule characteristics according to clinicopathological factors in clinical T1a renal tumors #MMPMID26617856
  • Kim M; Choi WS; Jeong CW; Ku JH; Kim HH; Moon KC; Kwak C
  • Int J Clin Exp Pathol 2015[]; 8 (9): 11323-31 PMID26617856show ga
  • Objectives: To evaluate the status of peritumoral pseudocapsules in renal tumors and the effects of clinicopathological factors on their formation. Methods: From January 2011 to December 2012, 258 patients with solitary clinical stage T1a renal tumors who underwent partial nephrectomy were analyzed. Status of pseudocapsule was re-evaluated by a pathologist. Results: The mean long diameter (± SD) of the tumor and the width of the safety margin were 2.17 (± 0.94) cm and 3.2 (± 2.4) mm, respectively. A complete pseudocapsule was identified in 152 (58.9%) tumors, an incomplete pseudocapsule was identified in 69 (26.7%) tumors, and no pseudocapsule was identified in 37 (14.3%) tumors. Out of 152 tumors with complete pseudocapsules, 45 (29.6%) were confirmed to directly invade the renal parenchyma. In a multivariable analysis, age (odds ratio [OR], 1.045; 95% confidence interval [CI], 1.021-1.070, P < 0.001) and histologic subtype (chromophobe type: OR, 19.455; 95% CI, 4.233-89.471, P < 0.001; oncocytoma: OR, 11.307; 95% CI, 1.357-94.198, P = 0.025) were significant factors for an incomplete or absent pseudocapsule. Conclusions: Peritumoral pseudocapsules are absent or incomplete in a significant portion of renal tumors. Old age as well as chromophobe and oncocytoma histologic subtypes were significant risk factors for an incomplete or absent peritumoral pseudocapsule.
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