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MiR-142-3p functions as a potential tumor suppressor directly targeting HMGB1 in non-small-cell lung carcinoma |pdf=|usr=}}{{26617792 }} gab.com Text MiR-142-3p functions as a potential tumor suppressor directly targeting HMGB1 in non-small-cell lung carcinoma JO: Int J Clin Exp Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26617792 #FOAvip BACKGROUND: microRNAs (miRNAs) play a significant role in cancer development and progression by regulating the expression of oncogenes or tumor suppressor genes. Previous study using microarrays demonstrated that miR-142-3p was downregulated in patients with Non-small-cell lung carcinoma (NSCLC). However, the functional role of miR-142-3p in NSCLC is still unclear. MATERIAL AND METHOD: Real-time quantitative PCR was applied to evaluate the expression level of miRNA-142-3p in NSCLC and normal samples. The cell proliferation of NSCLC cells was analyzed by MTT and colony formation assay after miR-142-3p transfection. Luciferase activities assay, cotransfection and Western blot were used to reveal that the predicted target genes of miR-125b were direct and specific. RESULTS: In this study, we demonstrate miR-142-3p was downregulated in NSCLC tissues and cell lines. We demonstrated that the overexpression of miR-142-3p inhibits NSCLC cell proliferation and induced cell apoptosis. Furthermore, we demonstrate HMGB1 was a directly target of miR-142-3p in NSCLC cells, and confirmed the target specificity between miR-142-3p and the HMGB1 3'-untranslated region by luciferase reporter assay. CONCLUSIONS: These results suggest that miR-142-3p may be a tumor suppressor through the downregulation of HMGB1 in NSCLC. miR-142-3p may be a tumor suppressor and a potential therapeutic agent for patients with NSCLC. Twit Text FOAVip MiR-142-3p functions as a potential tumor suppressor directly targeting HMGB1 in non-small-cell lung carcinoma ????Int J Clin Exp Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26617792 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26617792 #FOAvip English Wikipedia <ref>{{Cite pmid|26617792 }}</ref> MiR-142-3p functions as a potential tumor suppressor directly targeting HMGB1 in non-small-cell lung carcinoma #MMPMID26617792 Xiao P ; Liu WL Int J Clin Exp Pathol 2015[]; 8 (9 ): 10800-7 PMID26617792 show ga BACKGROUND: microRNAs (miRNAs) play a significant role in cancer development and progression by regulating the expression of oncogenes or tumor suppressor genes. Previous study using microarrays demonstrated that miR-142-3p was downregulated in patients with Non-small-cell lung carcinoma (NSCLC). However, the functional role of miR-142-3p in NSCLC is still unclear. MATERIAL AND METHOD: Real-time quantitative PCR was applied to evaluate the expression level of miRNA-142-3p in NSCLC and normal samples. The cell proliferation of NSCLC cells was analyzed by MTT and colony formation assay after miR-142-3p transfection. Luciferase activities assay, cotransfection and Western blot were used to reveal that the predicted target genes of miR-125b were direct and specific. RESULTS: In this study, we demonstrate miR-142-3p was downregulated in NSCLC tissues and cell lines. We demonstrated that the overexpression of miR-142-3p inhibits NSCLC cell proliferation and induced cell apoptosis. Furthermore, we demonstrate HMGB1 was a directly target of miR-142-3p in NSCLC cells, and confirmed the target specificity between miR-142-3p and the HMGB1 3'-untranslated region by luciferase reporter assay. CONCLUSIONS: These results suggest that miR-142-3p may be a tumor suppressor through the downregulation of HMGB1 in NSCLC. miR-142-3p may be a tumor suppressor and a potential therapeutic agent for patients with NSCLC. |3' Untranslated Regions [MESH] |Aged [MESH] |Apoptosis [MESH] |Binding Sites [MESH] |Carcinoma, Non-Small-Cell Lung/genetics/*metabolism/pathology [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation [MESH] |Computational Biology [MESH] |Databases, Genetic [MESH] |Female [MESH] |Gene Expression Regulation, Neoplastic [MESH] |HMGB1 Protein/genetics/*metabolism [MESH] |Humans [MESH] |Lung Neoplasms/genetics/*metabolism/pathology [MESH] |Male [MESH] |MicroRNAs/genetics/*metabolism [MESH] |Middle Aged [MESH] |Signal Transduction [MESH] |Time Factors [MESH]MiR-142-3p functions as a potential tumor suppressor directly targetin(epmc).pdf DeepDyve Pubget Overpricing