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http://scihub22266oqcxt.onion/ C4637590!4637590 !26617775     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26617775 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Clin+Exp+Pathol 2015 ; 8 (9 ): 10653-61 Nephropedia Template TP {{tp|p=26617775 |t=2015. Fenofibrate, a PPAR? agonist, protect proximal tubular cells from albumin-bound fatty acids induced apoptosis via the activation of NF-kB |pdf=|usr=}}{{26617775 }} gab.com Text Fenofibrate, a PPAR agonist, protect proximal tubular cells from albumin-bound fatty acids induced apoptosis via the activation of NF-kB JO: Int J Clin Exp Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26617775 #FOAvip Albumin-bound fatty acids is the main cause of renal damage, PPAR? is responsible in the metabolism of fatty acids. Previous study found that PPAR? played a protective role in fatty acids overload associated tubular injury. The aim of the present study is to investigate whether fenofibrate, a PPAR? ligands, could contribute to the renoprotective action in fatty acids overload proximal tubule epithelial cells. We observed in HK-2 cells that fenofibrate significantly inhibited fatty acids bound albumin (FA-BSA) induced up-regulation of MCP-1 and IL-8. Treatment with fenofibrate attenuated renal oxidative stress induced by FA-BSA as evidenced by decreased MDA level, increased SOD activity and catalase, GPx-1 expression. FA-BSA induced apoptosis of HK-2 cells were also obviously prevented by fenofibrate. Furthermore, fenofibrate significantly increased the expression of PPAR? mRNA and protein in FA-BSA treated cells. Finally, the activation of NF-kB induced by FA-BSA was markedly suppressed by fenofibrate. Taken together, our study describes a renoprotective role of fenofibrate in fatty acids associated tubular toxicity, and the transcriptional activation of PPAR? and suppression of NF-kB were at least partially involved. Twit Text FOAVip Fenofibrate, a PPAR agonist, protect proximal tubular cells from albumin-bound fatty acids induced apoptosis via the activation of NF-kB ????Int J Clin Exp Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26617775 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26617775 #FOAvip English Wikipedia <ref>{{Cite pmid|26617775 }}</ref> Fenofibrate, a PPAR? agonist, protect proximal tubular cells from albumin-bound fatty acids induced apoptosis via the activation of NF-kB #MMPMID26617775 Zuo N ; Zheng X ; Liu H ; Ma X Int J Clin Exp Pathol 2015[]; 8 (9 ): 10653-61 PMID26617775 show ga Albumin-bound fatty acids is the main cause of renal damage, PPAR? is responsible in the metabolism of fatty acids. Previous study found that PPAR? played a protective role in fatty acids overload associated tubular injury. The aim of the present study is to investigate whether fenofibrate, a PPAR? ligands, could contribute to the renoprotective action in fatty acids overload proximal tubule epithelial cells. We observed in HK-2 cells that fenofibrate significantly inhibited fatty acids bound albumin (FA-BSA) induced up-regulation of MCP-1 and IL-8. Treatment with fenofibrate attenuated renal oxidative stress induced by FA-BSA as evidenced by decreased MDA level, increased SOD activity and catalase, GPx-1 expression. FA-BSA induced apoptosis of HK-2 cells were also obviously prevented by fenofibrate. Furthermore, fenofibrate significantly increased the expression of PPAR? mRNA and protein in FA-BSA treated cells. Finally, the activation of NF-kB induced by FA-BSA was markedly suppressed by fenofibrate. Taken together, our study describes a renoprotective role of fenofibrate in fatty acids associated tubular toxicity, and the transcriptional activation of PPAR? and suppression of NF-kB were at least partially involved. |Apoptosis/*drug effects [MESH] |Cell Line [MESH] |Cell Proliferation/drug effects [MESH] |Cell Survival/drug effects [MESH] |Chemokine CCL2/metabolism [MESH] |Cytoprotection [MESH] |Dose-Response Relationship, Drug [MESH] |Fatty Acids/metabolism/*toxicity [MESH] |Fenofibrate/*pharmacology [MESH] |Humans [MESH] |Interleukin-8/metabolism [MESH] |Kidney Tubules, Proximal/*drug effects/metabolism/pathology [MESH] |Malondialdehyde/metabolism [MESH] |NF-kappa B/*metabolism [MESH] |Oxidative Stress/drug effects [MESH] |PPAR alpha/*agonists/genetics/metabolism [MESH] |Protein Binding [MESH] |Serum Albumin, Bovine/metabolism/*toxicity [MESH] |Signal Transduction/drug effects [MESH] |Superoxide Dismutase/metabolism [MESH] |Transcription, Genetic/drug effects [MESH] |Transcriptional Activation/drug effects [MESH]Fenofibrate, a PPAR? agonist, protect proximal tubular cells from albu(epmc).pdf DeepDyve Pubget Overpricing