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http://scihub22266oqcxt.onion/ C4637527!4637527 !26617712     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26617712 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Int+J+Clin+Exp+Pathol 2015 ; 8 (9 ): 10050-60 Nephropedia Template TP {{tp|p=26617712 |t=2015. MicroRNA-214 induces dendritic cell switching from tolerance to immunity by targeting ?-Catenin signaling |pdf=|usr=}}{{26617712 }} gab.com Text MicroRNA-214 induces dendritic cell switching from tolerance to immunity by targeting -Catenin signaling JO: Int J Clin Exp Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26617712 #FOAvip MicroRNAs (miRNAs) are known to function as negative gene regulators. Recently, miRNAs have been shown to regulate immunity processes; however, the mechanism is unclear. The role of microRNA-214 (miR-214) in dendritic cell (DC) maturation has not been investigated. We found that the miR-214 level was correlated with the maturation of DCs and inflammatory cytokine secretion, as depressed miR-214 levels induced DC tolerance. We also identified ?-catenin as a target gene of miR-214 and demonstrated its association with Treg cell differentiation. MiR-214 regulates gene expression by binding to the 3'UTR of ?-catenin. The results suggest that ?-catenin is a critical regulator of tolerance in DCs via miR-214. The expression of miR-214 could be a potential therapeutic strategy in organ transplantation or autoimmunity patients. Twit Text FOAVip MicroRNA-214 induces dendritic cell switching from tolerance to immunity by targeting -Catenin signaling ????Int J Clin Exp Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26617712 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26617712 #FOAvip English Wikipedia <ref>{{Cite pmid|26617712 }}</ref> MicroRNA-214 induces dendritic cell switching from tolerance to immunity by targeting ?-Catenin signaling #MMPMID26617712 Gu C ; Zhou XD ; Yuan Y ; Miao XH ; Liu Y ; Ru YW ; Li KQ ; Li G Int J Clin Exp Pathol 2015[]; 8 (9 ): 10050-60 PMID26617712 show ga MicroRNAs (miRNAs) are known to function as negative gene regulators. Recently, miRNAs have been shown to regulate immunity processes; however, the mechanism is unclear. The role of microRNA-214 (miR-214) in dendritic cell (DC) maturation has not been investigated. We found that the miR-214 level was correlated with the maturation of DCs and inflammatory cytokine secretion, as depressed miR-214 levels induced DC tolerance. We also identified ?-catenin as a target gene of miR-214 and demonstrated its association with Treg cell differentiation. MiR-214 regulates gene expression by binding to the 3'UTR of ?-catenin. The results suggest that ?-catenin is a critical regulator of tolerance in DCs via miR-214. The expression of miR-214 could be a potential therapeutic strategy in organ transplantation or autoimmunity patients. |Animals [MESH] |Cell Differentiation [MESH] |Cells, Cultured [MESH] |Dendritic Cells/immunology/*metabolism [MESH] |Immune Tolerance/*genetics [MESH] |Mice [MESH] |MicroRNAs/genetics/*metabolism [MESH] |Signal Transduction/*genetics [MESH] |T-Lymphocytes, Regulatory/immunology/metabolism [MESH] |Wnt Signaling Pathway/genetics [MESH]MicroRNA-214 induces dendritic cell switching from tolerance to immuni(epmc).pdf DeepDyve Pubget Overpricing