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10.1007/s00109-015-1329-4 http://scihub22266oqcxt.onion/10.1007/s00109-015-1329-4 C4636917!4636917!26275789     free     free     free       J+Mol+Med+(Berl) 2015 ; 93 (11): 1203-12 Nephropedia Template TP {{tp|p=26275789|t=2015. Bone metastasis and the metastatic niche |pdf=|usr=}}{{26275789}} gab.com Text Bone metastasis and the metastatic niche JO: J Mol Med (Berl) http://www.kidney.de/pget.php?&tw=1&pmid=26275789 #FOAvip The bone marrow has been long known to host a unique environment amenable to colonization by metastasizing tumor cells. Yet, the underlying molecular interactions within this specialized microenvironment which give rise to the high incidence of bone metastasis in breast and prostate cancer patients have long remained uncharacterized. With the recent description of the bone metastatic ?niche,? considerable focus has been placed on understanding how the bone stroma contributes to each step of metastasis. Discoveries within this field have demonstrated that when cancer cells home to the niche in which hematopoietic and mesenchymal stem/progenitor cells normally reside, a bidirectional crosstalk emerges between the tumor cells and the bone metastatic stroma. This communication modulates every step of cancer cell metastasis to the bone, including the initial homing and seeding, formation of micrometastases, outgrowth of macrometastases, and the maintenance of long-term dormancy of disseminated tumor cells in bone. In clinical practice, targeting the bone metastatic niche is evolving into a promising avenue for the prevention of bone metastatic relapse, therapeutic resistance, and other aspects of cancer progression. Here, we review the current knowledge concerning the role of the bone metastatic niche in bone metastasis. Twit Text FOAVip Bone metastasis and the metastatic niche ????J Mol Med (Berl) http://www.kidney.de/pget.php?&tw=1&pmid=26275789 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26275789 #FOAvip English Wikipedia <ref>{{Cite pmid|26275789}}</ref> Bone metastasis and the metastatic niche #MMPMID26275789 Ren G; Esposito M; Kang Y J Mol Med (Berl) 2015[Nov]; 93 (11): 1203-12 PMID26275789show ga The bone marrow has been long known to host a unique environment amenable to colonization by metastasizing tumor cells. Yet, the underlying molecular interactions within this specialized microenvironment which give rise to the high incidence of bone metastasis in breast and prostate cancer patients have long remained uncharacterized. With the recent description of the bone metastatic ?niche,? considerable focus has been placed on understanding how the bone stroma contributes to each step of metastasis. Discoveries within this field have demonstrated that when cancer cells home to the niche in which hematopoietic and mesenchymal stem/progenitor cells normally reside, a bidirectional crosstalk emerges between the tumor cells and the bone metastatic stroma. This communication modulates every step of cancer cell metastasis to the bone, including the initial homing and seeding, formation of micrometastases, outgrowth of macrometastases, and the maintenance of long-term dormancy of disseminated tumor cells in bone. In clinical practice, targeting the bone metastatic niche is evolving into a promising avenue for the prevention of bone metastatic relapse, therapeutic resistance, and other aspects of cancer progression. Here, we review the current knowledge concerning the role of the bone metastatic niche in bone metastasis. äBone metastasis and the metastatic niche (epmc).pdf DeepDyve Pubget Overpricing