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2015 ; 59
(ä): 29678
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Anticipatory and consummatory effects of (hedonic) chocolate intake are
associated with increased circulating levels of the orexigenic peptide ghrelin
and endocannabinoids in obese adults
#MMPMID26546790
Rigamonti AE
; Piscitelli F
; Aveta T
; Agosti F
; De Col A
; Bini S
; Cella SG
; Di Marzo V
; Sartorio A
Food Nutr Res
2015[]; 59
(ä): 29678
PMID26546790
show ga
BACKGROUND: Hedonic hunger refers to consumption of food just for pleasure and
not to maintain energy homeostasis. Recently, consumption of food for pleasure
was reported to be associated with increased circulating levels of both the
orexigenic peptide ghrelin and the endocannabinoid 2-arachidonoyl-glycerol (2-AG)
in normal-weight subjects. To date, the effects of hedonic hunger, and in
particular of chocolate craving, on these mediators in obese subjects are still
unknown. METHODS: To explore the role of some gastrointestinal orexigenic and
anorexigenic peptides and endocannabinoids (and some related congeners) in
chocolate consumption, we measured changes in circulating levels of ghrelin,
glucagon-like peptide 1 (GLP-1), peptide YY (PYY), anandamide (AEA), 2-AG,
palmitoylethanolamide (PEA), and oleoylethanolamide (OEA) in 10 satiated severely
obese subjects after consumption of chocolate and, on a separate day, of a
non-palatable isocaloric food with the same bromatologic composition. Evaluation
of hunger and satiety was also performed by visual analogic scale. RESULTS: The
anticipatory phase and the consumption of food for pleasure were associated with
increased circulating levels of ghrelin, AEA, 2-AG, and OEA. In contrast, the
levels of GLP-1, PYY, and PEA did not differ before and after the
exposure/ingestion of either chocolate or non-palatable foods. Hunger and satiety
were higher and lower, respectively, in the hedonic session than in the
non-palatable one. CONCLUSIONS: When motivation to eat is generated by exposure
to, and consumption of, chocolate a peripheral activation of specific endogenous
rewarding chemical signals, including ghrelin, AEA, and 2-AG, is observed in
obese subjects. Although preliminary, these findings predict the effectiveness of
ghrelin and endocannabinoid antagonists in the treatment of obesity.