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10.1038/nm.3967 http://scihub22266oqcxt.onion/10.1038/nm.3967 C4636487!4636487!26457759     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Med 2015 ; 21 (11): 1350-6 Nephropedia Template TP {{tp|p=26457759|t=2015. The Consensus Molecular Subtypes of Colorectal Cancer |pdf=|usr=}}{{26457759}} gab.com Text The Consensus Molecular Subtypes of Colorectal Cancer JO: Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=26457759 #FOAvip Colorectal cancer (CRC) is a frequently lethal disease with heterogeneous outcomes and drug responses. To resolve inconsistencies among the reported gene expression?based CRC classifications and facilitate clinical translation, we formed an international consortium dedicated to large-scale data sharing and analytics across expert groups. We show marked interconnectivity between six independent classification systems coalescing into four consensus molecular subtypes (CMS) with distinguishing features: CMS1 (MSI Immune, 14%), hypermutated, microsatellite unstable, strong immune activation; CMS2 (Canonical, 37%), epithelial, chromosomally unstable, marked WNT and MYC signaling activation; CMS3 (Metabolic, 13%), epithelial, evident metabolic dysregulation; and CMS4 (Mesenchymal, 23%), prominent transforming growth factor ? activation, stromal invasion, and angiogenesis. Samples with mixed features (13%) possibly represent a transition phenotype or intra-tumoral heterogeneity. We consider the CMS groups the most robust classification system currently available for CRC ? with clear biological interpretability ? and the basis for future clinical stratification and subtype?based targeted interventions. Twit Text FOAVip The Consensus Molecular Subtypes of Colorectal Cancer ????Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=26457759 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26457759 #FOAvip English Wikipedia <ref>{{Cite pmid|26457759}}</ref> The Consensus Molecular Subtypes of Colorectal Cancer #MMPMID26457759 Guinney J; Dienstmann R; Wang X; de Reyniès A; Schlicker A; Soneson C; Marisa L; Roepman P; Nyamundanda G; Angelino P; Bot BM; Morris JS; Simon IM; Gerster S; Fessler E; de Sousa e Melo F; Missiaglia E; Ramay H; Barras D; Homicsko K; Maru D; Manyam GC; Broom B; Boige V; Perez-Villamil B; Laderas T; Salazar R; Gray JW; Hanahan D; Tabernero J; Bernards R; Friend SH; Laurent-Puig P; Medema JP; Sadanandam A; Wessels L; Delorenzi M; Kopetz S; Vermeulen L; Tejpar S Nat Med 2015[Nov]; 21 (11): 1350-6 PMID26457759show ga Colorectal cancer (CRC) is a frequently lethal disease with heterogeneous outcomes and drug responses. To resolve inconsistencies among the reported gene expression?based CRC classifications and facilitate clinical translation, we formed an international consortium dedicated to large-scale data sharing and analytics across expert groups. We show marked interconnectivity between six independent classification systems coalescing into four consensus molecular subtypes (CMS) with distinguishing features: CMS1 (MSI Immune, 14%), hypermutated, microsatellite unstable, strong immune activation; CMS2 (Canonical, 37%), epithelial, chromosomally unstable, marked WNT and MYC signaling activation; CMS3 (Metabolic, 13%), epithelial, evident metabolic dysregulation; and CMS4 (Mesenchymal, 23%), prominent transforming growth factor ? activation, stromal invasion, and angiogenesis. Samples with mixed features (13%) possibly represent a transition phenotype or intra-tumoral heterogeneity. We consider the CMS groups the most robust classification system currently available for CRC ? with clear biological interpretability ? and the basis for future clinical stratification and subtype?based targeted interventions. äThe Consensus Molecular Subtypes of Colorectal Cancer (epmc).pdf DeepDyve Pubget Overpricing